Peritoneal lymphomatosis as a rare entity of post-transplant lymphoproliferative disorder after kidney transplantation: a case report

被引：0

作者：

Shirai, Kana ^{[1
]}

Ogata, Masatomo ^{[1
]}

Murata-Hasegawa, Marie ^{[1
]}

Miyauchi, Masataka ^{[1
]}

Sakurai, Yuko ^{[2
]}

Shinoda, Kazunobu ^{[3
]}

Koike, Junki ^{[4
]}

Shibagaki, Yugo ^{[1
]}

Yazawa, Masahiko ^{[1
]}

机构：

[1] St Marianna Univ, Dept Internal Med, Div Nephrol & Hypertens, Sch Med, 2-16-1 Sugao,Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan

[2] St Marianna Univ, Dept Pharm, Sch Med, 2-16-1 Sugao,Miyamae Ku, Kawasaki, Kanagawa, Japan

[3] St Marianna Univ, Dept Urol, Sch Med, 2-16-1 Sugao,Miyamae Ku, Kawasaki, Kanagawa, Japan

[4] St Marianna Univ, Dept Pathol, Sch Med, 2-16-1 Sugao,Miyamae Ku, Kawasaki, Kanagawa, Japan

来源：

CEN CASE REPORTS | 2025年

关键词：

Kidney transplantation; PTLD; Post-transplant lymphoproliferative disorder; Peritoneallymphomatosis; Ascites; RISK-FACTORS; DIAGNOSIS; MASS; CT;

D O I：

10.1007/s13730-025-00976-5

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Post-transplant lymphoproliferative disorder (PTLD) is a severe complication of solid organ transplantation, and its manifestation as peritoneal lymphomatosis (PL) is extremely rare. This report describes the case of a 65-year-old kidney transplant recipient who presented with massive ascites as the initial symptom of PTLD 8 years post-transplantation. The patient experienced a sudden onset of ascites, and both his serum and ascitic fluid showed elevated lactate dehydrogenase (LDH) levels along with characteristic computed tomography (CT) findings, both of which raised the suspicion of lymphoma. The cytology of the ascitic fluid confirmed the diagnosis of peritoneal primary diffuse large B-cell lymphoma, leading to an early diagnosis of PL and management strategies. Although the patient developed tumor lysis syndrome soon after chemotherapy, prompt management led to complete remission. When ascites is observed in post-transplant recipients, it is essential to consider PTLD, recognize the diagnostic value of LDH levels and CT imaging, and emphasize the importance of early intervention to achieve favorable outcomes. To the best of our knowledge, this is the first reported case of PL in a kidney transplant recipient.

引用

页数：8

共 30 条

[1]

Dierickx D., Habermann T.M., Post-transplantation lymphoproliferative disorders in adults, N Engl J Med, 378, 6, pp. 549-562, (2018)

[2]

Atallah-Yunes S.A., Salman O., Robertson M.J., Post-transplant lymphoproliferative disorder: update on treatment and novel therapies, Br J Haematol, 201, 3, pp. 383-395, (2023)

[3]

Moller M.B., Pedersen N.T., Christensen B.E., Diffuse large B-cell lymphoma: clinical implications of extranodal versus nodal presentation–a population-based study of 1575 cases, Br J Haematol, 124, 2, pp. 151-159, (2004)

[4]

Morgans A.K., Reshef R., Tsai D.E., Posttransplant lymphoproliferative disorder following kidney transplant, Am J Kidney Dis, 55, 1, pp. 168-180, (2010)

[5]

Fujimi A., Nagamachi Y., Yamauchi N., Onoyama N., Hayasaka N., Matsuno T., Et al., High-grade B-cell lymphoma, not otherwise specified, presenting as primary peritoneal lymphomatosis and successfully treated with dose-adjusted EPOCH-R, J Clin Exp Hematop, 64, 1, pp. 37-44, (2024)

[6]

Ichikawa S., Fukuhara N., Saito K., Onodera K., Onishi Y., Yokoyama H., Et al., Diffuse large b-cell lymphoma presenting as peritoneal lymphomatosis: a case report and literature review, Intern Med, 61, 13, pp. 2057-2060, (2022)

[7]

Curakova E., Genadieva-Dimitrova M., Misevski J., Caloska-Ivanova V., Andreevski V., Todorovska B., Et al., NonHodgkin’s lymphoma with peritoneal localization, Case Rep Gastrointest Med, 2014, (2014)

[8]

Glazer H.S., Lee J.K., Balfe D.M., Mauro M.A., Griffith R., Sagel S.S., Non-Hodgkin lymphoma: computed tomographic demonstration of unusual extranodal involvement, Radiology, 149, 1, pp. 211-217, (1983)

[9]

Kim H.B., Hong R., Na Y.S., Choi W.Y., Park S.G., Lee H.J., Isolated peritoneal lymphomatosis defined as post-transplant lymphoproliferative disorder after a liver transplant: a case report, World J Clin Cases, 7, 24, pp. 4299-4306, (2019)

[10]

O'Neill A.C., Shinagare A.B., Rosenthal M.H., Tirumani S.H., Jagannathan J.P., Ramaiya N.H., Differences in CT features of peritoneal carcinomatosis, sarcomatosis, and lymphomatosis: retrospective analysis of 122 cases at a tertiary cancer institution, Clin Radiol, 69, 12, pp. 1219-1227, (2014)

← 1 2 3 →