Therapeutic potential of fecal microbiota transplantation in colorectal cancer based on gut microbiota regulation: from pathogenesis to efficacy

被引:0
|
作者
Gu, Chen [1 ]
Sha, Gengyu [1 ]
Zeng, Binbin [1 ]
Cao, Herong [1 ]
Cao, Yibo [2 ]
Tang, Dong [3 ,4 ,5 ,6 ]
机构
[1] Yangzhou Univ, Clin Med Coll, Yangzhou, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Sch Clin Med 2, Nanjing, Jiangsu, Peoples R China
[3] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Yangzhou 225000, Peoples R China
[4] Xuzhou Med Univ, Yangzhou Clin Coll, Xuzhou 221000, Peoples R China
[5] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Inst Gen Surg, Dept Gen Surg, Yangzhou 225000, Peoples R China
[6] Nanjing Univ, Northern Jiangsu Peoples Hosp, Clin Teaching Hosp, Med Sch, Nanjing 210000, Peoples R China
关键词
colorectal cancer; fecal microbiota transplantation; gut microbiome; microbiota-gut-brain; INFLAMMATORY-BOWEL-DISEASE; ESCHERICHIA-COLI; BARRIER FUNCTION; MOLECULAR REGULATION; CROSS-TALK; ASSOCIATION; METABOLISM; MECHANISMS; DISORDERS; RECEPTOR;
D O I
10.1177/17562848251327167
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Colorectal cancer (CRC) remains a leading cause of cancer-related deaths worldwide, with its progression intricately linked to gut microbiota dysbiosis. Disruptions in microbial homeostasis contribute to tumor initiation, immune suppression, and inflammation, establishing the microbiota as a key therapeutic target. Fecal microbiota transplantation (FMT) has emerged as a transformative approach to restore microbial balance, enhance immune responses, and reshape the tumor microenvironment. This review explores the mechanisms underlying FMT's therapeutic potential, evaluates its advantages over other microbiota-based interventions, and addresses challenges such as donor selection, safety concerns, and treatment standardization. Looking forward, the integration of FMT into personalized CRC therapies requires robust clinical trials and the identification of predictive biomarkers to optimize its efficacy and safety.
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页数:20
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