Background: Nearly half of congenital heart defects (CHDs) related to mortality occur during infancy although advancements in treatments have increased the survival rates. This study comprehensively examined overall and surgical mortality in CHD infants with the highest mortality rates in an effort to improve our understanding of CHD epidemiology. Methods: Participants were drawn from a dataset of 1,964,691 infants born between 2014 and 2018 in Korea. Crucial CHDs are defined here as including diverse categorical defects and classical critical CHDs but excluding simple shunt defects. Overall mortality (procedural and natural mortality) and procedural mortality (interventional and surgical mortality) for infants were analyzed. Results: The performance rate for multiple procedures in infants with crucial CHDs was 16%. The overall and surgical mortalities of crucial CHDs were 8% and 7%. The mortalities of palliative procedures were relatively high. Procedural mortalities for infants were significantly decreased in the tetralogy of Fallot (TOF), atrioventricular septal defects, and total anomalous pulmonary venous return (TAPVR) compared with overall mortalities for infants. Surgical mortalities for infants involving TOF and TAPVR were significantly lower, but those for infants involving hypoplastic left heart syndrome (HLHS) were higher than those for all ages. Conclusions: Palliative procedural techniques in infants must be improved to obtain better outcomes, particularly in the palliative surgery of HLHS. The infantile procedural outcomes for TOF and TAPVR are excellent and important in order to overcome disastrous circumstances during infancy. This comprehensive study of the overall and procedural mortalities of CHDs may have laid a cornerstone for CHD epidemiology in Korean infants.
机构:
Ekurhuleni Dist Dept Hlth, ZA-1400 Gemiston, South Africa
Univ Witwatersrand, Fac Hlth Sci, Dept Obstet & Gynecol, Johannesburg, South Africa
Univ Pretoria, South African Med Res Council, Maternal & Infant Hlth Care Strategies Unit, Pretoria, South Africa
Univ Adelaide, Ekurhuleni Clin Res Ctr, JBI Affiliated Grp, Adelaide, AustraliaEkurhuleni Dist Dept Hlth, ZA-1400 Gemiston, South Africa
Basu, Jayati Kusari
Stewart, Aimee
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Univ Witwatersrand, Fac Hlth Sci, Sch Therapeut Sci, Physiotherapy Dept, Johannesburg, South AfricaEkurhuleni Dist Dept Hlth, ZA-1400 Gemiston, South Africa
Stewart, Aimee
Feucht, Ute
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Univ Pretoria, South African Med Res Council, Maternal & Infant Hlth Care Strategies Unit, Pretoria, South Africa
Univ Adelaide, Ekurhuleni Clin Res Ctr, JBI Affiliated Grp, Adelaide, Australia
Univ Pretoria, Dept Pediat, Pretoria, South Africa
Univ Pretoria, Res Ctr Maternal Fetal Newborn & Child Hlth Care S, Pretoria, South AfricaEkurhuleni Dist Dept Hlth, ZA-1400 Gemiston, South Africa
Feucht, Ute
Wing, Jeffrey
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Univ Witwatersrand, Charlotte Maxeke Johannesburg Acad Hosp, Fac Hlth Sci, Dept Internal Med, Johannesburg, South AfricaEkurhuleni Dist Dept Hlth, ZA-1400 Gemiston, South Africa
Wing, Jeffrey
Basu, Debashis
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Univ Adelaide, Ekurhuleni Clin Res Ctr, JBI Affiliated Grp, Adelaide, Australia
Univ Pretoria, Steve Biko Acad Hosp, Dept Publ Hlth Med, Pretoria, South AfricaEkurhuleni Dist Dept Hlth, ZA-1400 Gemiston, South Africa
机构:
Hlth Care Inst Profozic, Occupat Hlth & Sports Med Unit, Zagreb, CroatiaHlth Care Inst Profozic, Occupat Hlth & Sports Med Unit, Zagreb, Croatia
Bozic, Tajana
Mestrovic, Tomislav
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Polyclin Dr Zora Profozic, Bostuska 19, Zagreb 10000, CroatiaHlth Care Inst Profozic, Occupat Hlth & Sports Med Unit, Zagreb, Croatia
Mestrovic, Tomislav
Profozic, Zora
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Hlth Care Inst Profozic, Occupat Hlth & Sports Med Unit, Zagreb, Croatia
Polyclin Dr Zora Profozic, Bostuska 19, Zagreb 10000, CroatiaHlth Care Inst Profozic, Occupat Hlth & Sports Med Unit, Zagreb, Croatia
Profozic, Zora
Profozic, Velimir
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Hlth Care Inst Profozic, Occupat Hlth & Sports Med Unit, Zagreb, Croatia
Polyclin Dr Zora Profozic, Bostuska 19, Zagreb 10000, CroatiaHlth Care Inst Profozic, Occupat Hlth & Sports Med Unit, Zagreb, Croatia
机构:Konkuk Univ, Med Ctr, Sch Med, Dept Cardiovasc Surg, Seoul 143429, South Korea
Shin, Hong Ju
Kim, Young-Hwue
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机构:Konkuk Univ, Med Ctr, Sch Med, Dept Cardiovasc Surg, Seoul 143429, South Korea
Kim, Young-Hwue
Ko, Jae-Kon
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机构:Konkuk Univ, Med Ctr, Sch Med, Dept Cardiovasc Surg, Seoul 143429, South Korea
Ko, Jae-Kon
Park, In-Sook
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机构:Konkuk Univ, Med Ctr, Sch Med, Dept Cardiovasc Surg, Seoul 143429, South Korea
Park, In-Sook
Seo, Dong Man
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Konkuk Univ, Med Ctr, Sch Med, Dept Cardiovasc Surg, Seoul 143429, South KoreaKonkuk Univ, Med Ctr, Sch Med, Dept Cardiovasc Surg, Seoul 143429, South Korea
机构:
Evelina London Children Hosp, Dept Neonatol, London, England
Monash Univ, Dept Paediat, Melbourne, Vic, AustraliaEvelina London Children Hosp, Dept Neonatol, London, England
Hernstadt, Hayley
Regan, William
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Evelina London Childrens Hosp, Dept Paediat Cardiol, London, EnglandEvelina London Children Hosp, Dept Neonatol, London, England
Regan, William
Bhatt, Hitarth
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Evelina London Childrens Hosp, Dept Paediat Cardiol, London, EnglandEvelina London Children Hosp, Dept Neonatol, London, England
Bhatt, Hitarth
Rosenthal, Eric
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Evelina London Childrens Hosp, Dept Paediat Cardiol, London, EnglandEvelina London Children Hosp, Dept Neonatol, London, England
Rosenthal, Eric
Meau-Petit, Virginie
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Evelina London Children Hosp, Dept Neonatol, London, EnglandEvelina London Children Hosp, Dept Neonatol, London, England