A case of high-grade adenosquamous carcinoma of the breast: case report and literature review

被引：0
作者：
Xing, Xiaoxiao [1 ]
Li, Junyi [1 ]
Fan, Yangyang [2 ]
Wang, Yun [3 ]
Wang, Yue [1 ]
Liao, Daixiang [1 ]
Zhang, Shiyun [1 ]
机构：
[1] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Surg, Beijing, Peoples R China
[2] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Radiol, Beijing, Peoples R China
[3] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Pathol, Beijing, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2025年 / 15卷
关键词：
high-grade adenosquamous carcinoma; metaplastic breast cancer; case report; breast cancer surgery; adjuvant chemotherapy; METAPLASTIC CARCINOMA; PROGNOSIS; CANCER; TUMORS;
D O I：
10.3389/fonc.2025.1548036
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
High-grade adenosquamous carcinoma (HGASC) is a rare and aggressive subtype of metaplastic breast cancer (MpBC). This article reports a case of HGASC (pT2N0M0 Stage IIA) in a 43-year-old female and reviews the relevant literature, with a specific focus on distinguishing HGASC from other MpBC subtypes, particularly low-grade adenosquamous carcinoma (LGASC). The patient underwent a skin-sparing mastectomy with abdominal rectus myocutaneous flap reconstruction. Histopathology confirmed HGASC with metaplastic features. Postoperative adjuvant chemotherapy with capecitabine was administered. The case highlights the unique clinical, imaging, and pathological characteristics of HGASC, its therapeutic challenges, and the need for individualized treatment strategies. A five-month follow-up showed no signs of recurrence or metastasis.
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页数：6
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