Direct β-C-H ketoalkylation of enaminoesters with cyclopropanols under metal-free conditions

被引：0

作者：

Zhan, Jun-Long ^{[1
,2
]}

Zhou, Sai-Nan ^{[1
]}

Wang, Yu ^{[1
]}

Liu, Rui ^{[1
]}

Wang, Yu-Tong ^{[1
]}

Tian, Mengke ^{[1
]}

Meng, Qiang ^{[3
]}

Zhu, Lin ^{[1
]}

Kong, Xiangtao ^{[1
]}

Lv, Yunhe ^{[1
]}

机构：

[1] Anyang Normal Univ, Coll Chem & Chem Engn, Henan Prov Engn & Technol Res Ctr Precise Synth Fl, Anyang 455000, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[3] Monash Univ, Sch Chem, Wellington Rd, Clayton, Vic 3800, Australia

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年 / 23卷 / 08期

关键词：

N-ARYL ENAMINES; INDOLES; KETONES; ANNULATION; ALDEHYDES; ESTERS;

D O I：

10.1039/d4ob01968g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A TEMPO-mediated beta-ketoalkylation of enaminoesters with cyclopropanols under metal-free conditions is herein described. This reaction provides a straightforward and highly efficient route to beta-keto alkyl substituted enaminoesters for the first time, which could be rapidly and efficiently converted into synthetically useful 2-alkoxycarbonyl functionalized 1,5-diketones. Moreover, the practicability of this protocol is successfully demonstrated by scale-up experiments and the late-stage functionalization of natural products and pharmaceutically relevant molecules.

引用

页码：1823 / 1827

页数：5

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