An Overview of Pyridazinone Analogs: Chemical and Pharmacological Potential

被引:1
作者
Boukharsa, Youness [1 ,2 ]
Karrouchi, Khalid [3 ]
Attjioui, Houda [4 ]
Ansar, M'Hammed [1 ]
机构
[1] Mohammed V Univ, Lab Med Chem, Fac Med & Pharm, Rabat, Morocco
[2] Higher Inst Nursing Profess & Tech Hlth ISPITS, Casablanca, Morocco
[3] Mohammed V Univ, Fac Med & Pharm, Lab Analyt Chem & Bromatol, Rabat, Morocco
[4] Abdelmalek Essaadi Univ, Fac Med & Pharm Tangier, Life Sci & Hlth Lab, Tetouan, Morocco
关键词
Heterocyclic chemistry; pyridazinone; pharmacological activities; structure-activity relationships; organic chemistry; alpha-diketones; CROSS-COUPLING REACTION; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; IN-VIVO; DERIVATIVES; INHIBITORS; DESIGN; ANTICANCER; AGENTS; PYRIDAZIN-3(2H)-ONES;
D O I
10.2174/0113895575287746240528072330
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Pyridazinones are classical molecules that occupy an important place in heterocyclic chemistry, and since their discovery, they have been widely developed. The introduction of new functional groups into pyridazinone structures has enabled the synthesis of a large diversity of compounds. The pharmacological and agrochemical importance of pyridazinone derivatives has aroused the interest of chemists and directed their research toward the synthesis of new compounds with the aim of improving their biological effectiveness. In this review, we have compiled and discussed the different synthetic routes, reactivity, and pharmacological and agrochemical applications of the pyridazinone ring.
引用
收藏
页码:3 / 26
页数:24
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