A new pyrrolopyrazine alkaloid from the fruit of Lycium chinense

被引：0
作者：
Liu, Hui [1 ]
Fan, Yu-Xin [1 ]
Xu, Rui-Wen [1 ]
Zhu, Yan-Jie [1 ]
Xue, Gui-Min [1 ,2 ]
Sun, Yan-Jun [1 ,2 ]
Feng, Wei-Sheng [1 ,2 ]
Chen, Hui [1 ,2 ]
机构：
[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 405600, Peoples R China
[2] Henan Univ Chinese Med, Collaborat Innovat Ctr Resp Dis Diag Treatment & C, Zhengzhou 405600, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2025年
基金：
中国国家自然科学基金;
关键词：
Solanaceae; Lycium chinense; pyrrolopyrazine alkaloid; alpha-glucosidase inhibitory activity; PYRROLE ALKALOIDS;
D O I：
10.1080/10286020.2025.2475481
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new pyrrolopyrazine alkaloid, named lycipyrazine A (1), alone with seven known alkaloids (2-8), were isolated from the fruit of Lycium chinense. The structure of new compound 1 was determined using extensive 1D and 2D spectroscopic analyses, while its absolute configuration was determined by comparison of its experimental and calculated ECD spectra. Their alpha-glucosidase inhibitory activity was screened using acarbose as a positive control. Compound 4 showed strong inhibitory activity against alpha-glucosidase (IC50 = 3.04 +/- 0.38 mu M). This study enriched the structural diversity of alkaloids in L. chinense and provided further clues for searching new antidiabetic agents from natural sources.
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页数：6
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