Mitochondrial dynamics and metabolism in macrophages for cardiovascular disease: A review

被引:1
作者
Zhong, Yi-lang [1 ]
Xu, Chen-qin [1 ]
Li, Ji [2 ]
Liang, Zhi-qiang [2 ]
Wang, Miao-miao [1 ]
Ma, Chao [1 ]
Jia, Cheng-lin [1 ]
Cao, Yong-bing [1 ]
Chen, Jian [1 ,3 ,4 ]
机构
[1] Shanghai Univ Tradit Chinese Med, Shanghai TCM Integrated Hosp, Inst Vasc Anomalies, Shanghai 200082, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Shanghai TCM Integrated Hosp, Dept Vasc Dis, Shanghai 200082, Peoples R China
[3] Huangshan Univ, Anhui Prov Rural Revitalizat Collaborat Tech Serv, Huangshan 245041, Peoples R China
[4] Krirk Univ, Int Coll, Dept Publ Hlth, Bangkok, Thailand
基金
中国国家自然科学基金;
关键词
Mitochondria; Macrophages; Cardiovascular diseases; Durgs; NLRP3; INFLAMMASOME; M2; MACROPHAGES; GASDERMIN D; CELL-DEATH; ACTIVATION; FISSION; FERROPTOSIS; PHENOTYPE; INHIBITION; PROTECTS;
D O I
10.1016/j.phymed.2025.156620
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Background: Mitochondria regulate macrophage function, affecting cardiovascular diseases like atherosclerosis and heart failure. Their dynamics interact with macrophage cell death mechanisms, including apoptosis and necroptosis. Purpose: This review explores how mitochondrial dynamics and metabolism influence macrophage inflammation and cell death in CVDs, highlighting therapeutic targets for enhancing macrophage resilience and reducing CVD pathology, while examining molecular pathways and pharmacological agents involved. Study design: This is a narrative review that integrates findings from various studies on mitochondrial dynamics and metabolism in macrophages, their interactions with the endoplasmic reticulum (ER) and Golgi apparatus, and their implications for CVDs. The review also considers the potential therapeutic effects of pharmacological agents on these pathways. Methods: The review utilizes a comprehensive literature search to identify relevant studies on mitochondrial dynamics and metabolism in macrophages, their role in CVDs, and the effects of pharmacological agents on these pathways. The selected studies are analyzed and synthesized to provide insights into the complex relationships between mitochondria, the ER, and Golgi apparatus, and their implications for macrophage function and fate. Results: The review reveals that mitochondrial metabolism intertwines with cellular architecture and function, particularly through its intricate interactions with the ER and Golgi apparatus. Mitochondrial-associated membranes (MAMs) facilitate Ca2+ transfer from the ER to mitochondria, maintaining mitochondrial homeostasis during ER stress. The Golgi apparatus transports proteins crucial for inflammatory signaling, contributing to immune responses. Inflammation-induced metabolic reprogramming in macrophages, characterized by a shift from oxidative phosphorylation to glycolysis, underscores the multifaceted role of mitochondrial metabolism in regulating immune cell polarization and inflammatory outcomes. Notably, mitochondrial dysfunction, marked by heightened reactive oxygen species generation, fuels inflammatory cascades and promotes cell death, exacerbating CVD pathology. However, pharmacological agents such as Metformin, Nitazoxanide, and Galanin emerge as potential therapeutic modulators of these pathways, offering avenues for mitigating CVD progression. Conclusion: This review highlights mitochondrial dynamics and metabolism in macrophage inflammation and cell death in CVDs, suggesting therapeutic targets to improve macrophage resilience and reduce pathology, with new pharmacological agents offering treatment opportunities.
引用
收藏
页数:29
相关论文
共 331 条
[1]   Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis [J].
Adebayo, Mary ;
Singh, Seema ;
Singh, Ajay Pratap ;
Dasgupta, Santanu .
FASEB JOURNAL, 2021, 35 (06)
[2]   DRP1: At the Crossroads of Dysregulated Mitochondrial Dynamics and Altered Cell Signaling in Cancer Cells [J].
Adhikary, Ankita ;
Mukherjee, Agradeep ;
Banerjee, Riddhi ;
Nagotu, Shirisha .
ACS OMEGA, 2023, 8 (48) :45208-45223
[3]   Mitochondrial dynamics in macrophages: divide to conquer or unite to survive? [J].
Afroz, Syeda Farhana ;
Raven, Karoline D. ;
Lawrence, Grace M. E. P. ;
Kapetanovic, Ronan ;
Schroder, Kate ;
Sweet, Matthew J. .
BIOCHEMICAL SOCIETY TRANSACTIONS, 2023, 51 (01) :41-56
[4]   Dexamethasone induces aberrant macrophage immune function and apoptosis [J].
Ai, Fulu ;
Zhao, Guohua ;
Lv, Wu ;
Liu, Bin ;
Lin, Jie .
ONCOLOGY REPORTS, 2020, 43 (02) :427-436
[5]   Mitochondrial Fission and Fusion: Molecular Mechanisms, Biological Functions, and Related Disorders [J].
Al Ojaimi, Mode ;
Salah, Azza ;
El-Hattab, Ayman W. .
MEMBRANES, 2022, 12 (09)
[6]   Gene of the month: H3F3A and H3F3B [J].
Aldera, Alessandro Pietro ;
Govender, Dhirendra .
JOURNAL OF CLINICAL PATHOLOGY, 2022, 75 (01) :1-4
[7]   Bmal1 integrates mitochondrial metabolism and macrophage activation [J].
Alexander, Ryan K. ;
Liou, Yae-Huei ;
Knudsen, Nelson H. ;
Starost, Kyle A. ;
Xu, Chuanrui ;
Hyde, Alexander L. ;
Liu, Sihao ;
Jacobi, David ;
Liao, Nan-Shih ;
Lee, Chih-Hao .
ELIFE, 2020, 9
[8]   Selective Induction of Cell Death in Human M1 Macrophages by Smac Mimetics Is Mediated by cIAP-2 and RIPK-1/3 through the Activation of mTORC [J].
Ali, Hamza ;
Dong, Simon Xin Min ;
Gajanayaka, Niranjala ;
Cassol, Edana ;
Angel, Jonathan B. ;
Kumar, Ashok .
JOURNAL OF IMMUNOLOGY, 2021, 207 (09) :2359-2373
[9]   The Evolving Roles of Cardiac Macrophages in Homeostasis, Regeneration, and Repair [J].
Alvarez-Argote, Santiago ;
O'Meara, Caitlin C. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (15)
[10]   The Relationship between Reactive Oxygen Species and the cGAS/STING Signaling Pathway in the Inflammaging Process [J].
Andrade, Barbara ;
Jara-Gutierrez, Carlos ;
Paz-Araos, Marilyn ;
Vazquez, Mary Carmen ;
Diaz, Pablo ;
Murgas, Paola .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (23)