Application of Inorganic Carrier-Loaded Chiral Catalysts in Asymmetric Catalysis

Chiral substances play a pivotal role in numerous contemporary fields, and their synthesis heavily relies on chiral catalysts. However, traditional homogeneous catalysts suffer from significant drawbacks, including difficulty in separation from products and nonrecyclability. Immobilization of homogeneous catalysts onto a specific carrier offers an excellent solution to these challenges, significantly reducing the production cost. Consequently, this approach has emerged as an inevitable trend in the development of chiral catalysts. This review comprehensively summarizes representative examples of an asymmetric catalytic reactions using chiral catalysts immobilized on inorganic carriers over the last decade, classifies them according to the type of carrier, and elucidates the loading techniques and recycling methods associated with these carriers.