The global burden of chronic kidney disease due to glomerulonephritis: trends and predictions

被引：0
作者：
Wang, Xiaotong [1 ]
Liu, Zhaoyi [2 ]
Yi, Na [1 ]
Li, Liguo [1 ]
Ma, Li [1 ]
Yuan, Linyue [1 ]
Wang, Xuejiao [1 ]
机构：
[1] Anshan Steel Hosp, Ansteel Grp Gen Hosp, Dept Nephrol, 3 JianShen St, Anshan, Liaoning, Peoples R China
[2] Shenzhen Yantian Dist Peoples Hosp, Dept Gen Surg, Shenzhen, Guangdong, Peoples R China
来源：
INTERNATIONAL UROLOGY AND NEPHROLOGY | 2025年
关键词：
Glomerulonephritis; Chronic kidney disease; Global burden of disease; CKD;
D O I：
10.1007/s11255-025-04440-2
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
BackgroundGlomerulonephritis (GN), one of the primary causes of chronic kidney disease (CKD), is gaining recognition as a major public health issue. This research sought to evaluate the worldwide impact of chronic kidney disease due to glomerulonephritis (GN-CKD) between 1990 and 2021 and to forecast trends up to 2036, leveraging data from the Global Burden of Disease (GBD) study.MethodsThe analysis of GN-CKD from 1990 to 2021 utilized GBD open data as a secondary dataset to examine global prevalence, deaths, disability-adjusted life years (DALYs), and age-standardized rates of GN-CKD, and the changing trends of these indicators were statistically analyzed. To assess the practical difference between each country/region and the frontier, we utilized the 2021 DALYs and Socio-Demographic Index (SDI). To assist healthcare institutions in formulating more effective public health policies, the age-standardized mortality and DALYs rate until 2036 were predicted using Bayesian age-period-cohort (BAPC) modeling techniques.ResultsThe global prevalence rate of GN-CKD, as indicated by the age-standardized prevalence rate (ASPR), grew 10.81% between 1990 and 2021, with a marginal average annual change of 0.04 (AAPC0.04, 0.03-0.05). Similarly, there was an increase of 15.84% in the age-standardized death rate (ASDR) for GN-CKD during this period, with an average annual trend of 0.50 (AAPC0.50, 0.41-0.59). Moreover, the age-standardized DALYs rate (ASYR) for GN-CKD observed an upward trend of 8.60% from 1990 to 2021, with a modest average annual change of 0.27 (AAPC0.27, 0.17-0.37). Our findings indicate that the impact of GN-CKD differs across gender, geographic areas, and socioeconomic statuses. Elevated fasting plasma glucose levels, high body-mass index (BMI), and elevated systolic blood pressure were the main contributors to deaths and disability-adjusted life years (DALYs). Fortunately, the burden of GN-CKD is expected to diminish by 2036.ConclusionsThe worldwide impact of GN-CKD has risen, with variations observed between genders and across SDI regions. Encouraging trends point toward a potential reduction in GN-CKD-related burden in the future.
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页数：12
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