Chronic nausea and vomiting syndrome and impact on quality of life

Introduction and aim: Chronic nausea and vomiting syndrome is a disorder of gut-brain interaction that affects the productive-age population. Our aim was to determine the association of this disorder with quality of life, workplace performance, and socioeconomic impact related to gastrointestinal health. Methods: A cross-sectional study on a Mexican population was conducted. The patients were classified as having chronic nausea and vomiting syndrome or other disorders of gut-brain interaction. A comparative analysis of quality of life, workplace productivity, annual medical consultations, and digestive health-related expenses was carried out, applying a logistic regression model. Results: One thousand patients were included, 79.2% of whom met the criteria for a disorder of gut-brain interaction. Of the 792 patients, 10.3% presented with chronic nausea and vomiting syndrome. Said syndrome was associated with a negative impact on usual activities (OR 4.34, 95% CI 1.90-9.30, p <= 0.001), pain/discomfort (OR 2.09, 95% CI 1.31-3.33, p <= 0.001), anxiety/depression (OR 2.08, 95% CI 1.30-3.40, p <= 0.001), workplace presenteeism (OR 3.96, 95% CI 2.47-6.44, p <= 0.001), and workplace absenteeism (OR 2.54, 95% CI 1.52-4.16, p <= 0.001). There was also a higher number of annual medical consultations for digestive health (p = 0.013), without generating a greater annual expense due to digestive health (p = 0.08). Conclusions: Chronic nausea and vomiting syndrome produces a negative impact on quality of life, which could be secondary to its symptomatology or its association with anxiety and depression. (c) 2024 Asociacio<acute accent>n Mexicana de Gastroenterolog<acute accent>& imath;a. Published by Masson Doyma Me<acute accent>xico S.A. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/ by-nc-nd/4.0/).