BMP4-GPX4 can improve the ferroptosis phenotype of retinal ganglion cells and enhance their differentiation ability after retinal stem cell transplantation in glaucoma with high intraocular pressure

被引：0
作者：
Fang, Chuankai [1 ]
He, Di [2 ]
Qian, Yafen [3 ]
Shen, Xiaomei [1 ]
机构：
[1] Tongxiang First Peoples Hosp, Dept Oncol, 1918 Jiaochang East Rd, Tongxiang 314500, Zhejiang, Peoples R China
[2] Tongxiang First Peoples Hosp, Otorhinolaryngol, 1918 Jiaochang East Rd, Tongxiang 314500, Zhejiang, Peoples R China
[3] Tongxiang First Peoples Hosp, Dept Anesthesiol, 1918 Jiaochang East Rd, Tongxiang 314500, Zhejiang, Peoples R China
来源：
HUMAN MOLECULAR GENETICS | 2025年
关键词：
glaucoma; ferroptosis; BMP4; retinal stem cell;
D O I：
10.1093/hmg/ddaf011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Activation of bone morphogenetic protein (BMP) 4 signaling promotes the survival of retinal ganglion cell (RGC) after acute injury. In this study, we investigated the role of the BMP4 signaling pathway in regulating the degeneration of retinal ganglion cells (RGCs) in a mouse glaucoma model and its potential application in retinal stem cell. Our results demonstrate that BMP4-GPX4 not only reduces oxidative stress and iron accumulation but also promotes neuroprotective factors that support the survival of transplanted RSCs into the host retina. These findings suggest a novel therapeutic approach for glaucoma involving the modulation of the BMP4-GPX4 pathway to protect RGCs and improve visual function through enhanced RSC differentiation.
引用
收藏
页码：673 / 683
页数：11
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