Synthesis of silk sericin/silk fibroin/Moringa oleifera-based hydrogel with antibacterial activity

被引:0
作者
Hidayat, Muhammad Iqbal [1 ]
Hardiansyah, Andri [1 ]
Wardhani, Riesca Ayu Kusuma [1 ]
Khoiriah, Khoiriah [2 ]
Yulianti, Evi [3 ]
Yusuf, Muhammad Rayhan Izzati [4 ]
Fahrialdi, Fahrialdi [5 ]
机构
[1] Natl Res & Innovat Agcy BRIN, Res Ctr Nanotechnol Syst, South Tangerang City 15314, Banten, Indonesia
[2] Natl Res & Innovat Agcy BRIN, Res Ctr Chem, South Tangerang City 15314, Banten, Indonesia
[3] Natl Res & Innovat Agcy BRIN, Res Ctr Adv Mat, South Tangerang City 15314, Banten, Indonesia
[4] State Univ Jakarta, Fac Math & Nat Sci, Phys Dept, Jakarta 11520, Indonesia
[5] Prasetiya Mulya Univ, Fac Engn, Renewable Energy Engn Dept, Banten 15339, Tangerang Regio, Indonesia
关键词
Biomaterial; Hydrogel; Sericin; Fibroin; Moringa oleifera; Antibacterial properties; POLY(VINYL ALCOHOL); NANOCOMPOSITE; COMPOSITE; CHITOSAN; RELEASE;
D O I
10.1016/j.bcab.2024.103482
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Hydrogels with excellent antibacterial and mechanical properties represent ideal biomaterials for addressing skin defects, especially in burn wound dressings. In this study, PVA was combined with sericin (PVA/SS), fibroin (PVA/SF), sericin-Moringa oleifera (PVA/SS/MO), and fibroinMoringa oleifera (PVA/SF/MO) to enhance the stability of the resulting hydrogel and have the antibacterial properties. Hydrogels were synthesized through freezing at-15 degrees C for 20 h and thawing at 5 degrees C for 4 h (freeze-thawing method), this process diminished residual waste substances and aligning with green chemistry principles. The FTIR analysis demonstrated that all hydrogel components were successfully blended. The resulting hydrogel had a rough surface with many uniform pores by SEM measurement. Hydrogels showed very hydrophilic properties with lower values of contact angle measurement with a range of 12 and 33 degrees. The swelling properties of the hydrogel showed excellent performance and could absorb water for 5 days. The mechanical properties of the hydrogel were described as tensile strength of 0.29-0.77 MPa, tensile strain of 188-410%, elastic modulus of 0.18-0.72 MPa, and break elongation of 198-413%. Furthermore, PVA/SS/MO and PVA/SF/MO hydrogels display excellent antibacterial properties against Grampositive ( Staphylococcus aureus) and Gram-negative ( Escherichia coli) bacteria. Thus, the developing hydrogel is expected to be a future candidate for addressing skin defect problems due to wound infection.
引用
收藏
页数:17
相关论文
共 50 条
[41]   Multifunctional hydrogel based on silk fibroin/thermosensitive polymers supporting implant biomaterials in osteomyelitis [J].
Noosak, Chayanee ;
Jantorn, Pavarish ;
Thonglam, Jutakan ;
Chuaychoosakoon, Chaiwat ;
Meesane, Jirut ;
Sotthibandhu, Dennapa Saeloh .
E-POLYMERS, 2024, 24 (01)
[42]   Characterization of silk hydrogel formed with hydrolyzed silk fibroin-methacrylate via photopolymerization [J].
Kim, H. H. ;
Kim, J. W. ;
Choi, J. ;
Park, Y. H. ;
Ki, C. S. .
POLYMER, 2018, 153 :232-240
[43]   Silk fibroin and silk-based biomaterial derivatives for ideal wound dressings [J].
Patil, Priyanka P. ;
Reagan, Michaela R. ;
Bohara, Raghvendra A. .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 164 :4613-4627
[44]   PREPARATION AND PROPERTIES OF SILK FIBROIN HYDROGEL FOR BIOLOGICAL DRESSING [J].
XIE, Xusheng ;
WANG, Heng ;
LIU, Yu ;
XING, Zhanwen ;
ZHENG, Zhaozhu ;
WANG, Xiaoqin .
THERMAL SCIENCE, 2022, 26 (03) :2797-2804
[45]   Silk Sericin-Polyethyleneimine Hybrid Hydrogel with Excellent Structural Stability for Cr(VI) Removal [J].
Oh, Subin ;
Kim, Jungkyu ;
Kim, YunJin ;
Park, Subong ;
Jin, Hyoung-Joon ;
Kwak, Hyo Won .
MACROMOLECULAR RESEARCH, 2021, 29 (12) :895-904
[46]   Enhancing clinical applications of PVA hydrogel by blending with collagen hydrolysate and silk sericin [J].
Apirujee Punjataewakupt ;
Narendra Reddy ;
Pornanong Aramwit .
Journal of Polymer Research, 2022, 29
[47]   Nanoclay cross-linked semi-IPN silk sericin/poly(NIPAm/LMSH) nanocomposite hydrogel: An outstanding antibacterial wound dressing [J].
Yang, Chaochao ;
Xue, Rui ;
Zhang, Qingsong ;
Yang, Shulin ;
Liu, Pengfei ;
Chen, Li ;
Wang, Ke ;
Zhang, Xiaoyong ;
Wei, Yen .
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 81 :303-313
[48]   Enhancing clinical applications of PVA hydrogel by blending with collagen hydrolysate and silk sericin [J].
Punjataewakupt, Apirujee ;
Reddy, Narendra ;
Aramwit, Pornanong .
JOURNAL OF POLYMER RESEARCH, 2022, 29 (04)
[49]   Genetically engineered silk fibroin with antibacterial and antioxidant properties [J].
Manoharan, Chitra ;
Thomas, Dyna Susan ;
Yashwant, Rasalkar Sandhya ;
Roy, Gourab ;
Kunjupillai, Vijayan ;
Mishra, Rakesh Kumar ;
Nongthomba, Upendra ;
Gopalapillai, Ravikumar .
3 BIOTECH, 2025, 15 (05)
[50]   Characterization and Evaluation of Silk Sericin-Based Hydrogel: A Promising Biomaterial for Efficient Healing of Acute Wounds [J].
Munir, Fariha ;
Tahir, Hafiz Muhammad ;
Ali, Shaukat ;
Ali, Aamir ;
Tehreem, Ayesha ;
Zaidi, Syeda Durr E. Shahwar ;
Adnan, Muhammad ;
Ijaz, Fatima .
ACS OMEGA, 2023, :32090-32098