Development and Validation of a High-Performance Liquid Chromatographic Method for Content Assay of Ceftriaxone in Pharmaceutical Dosage

被引：0
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作者：
Hiremath, Basavaraj [1 ]
机构：
[1] SS Margol Coll Arts Sci & Commerce, Dept Chem, Kalaburagi 585228, Karnataka, India
来源：
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH | 2025年 / 59卷 / 01期
关键词：
HPLC; Ceftriaxone; Bulk; Pharmaceutical; Dosage; BETA-LACTAM ANTIBIOTICS; HUMAN PLASMA; FORMULATIONS; SODIUM; HPLC; DRUGS; SERUM;
D O I：
10.5530/ijper.20255575
中图分类号：
G40 [教育学];
学科分类号：
040101 ; 120403 ;
摘要：
Aim: A sensitive and accurate RP-HPLC method was developed and validated for the quantitative measurement of Ceftriaxone sodium (CEF) in pharmaceutical dosage forms and bulk medicine. Materials and Methods: Ceftriaxone sodium was separated on a 245 nm photodiode array detector using a Waters XTerra RP-18 (5 mu m 250x4.6 mm internal diameter) column. Results: The method generated an excellent linear response in the concentration range of 0.2-20 mu g/mL with remarkable precision of 0.16-0.7% and accuracy in the percent recovery range of 99.88-99.97%. Conclusion: We find the reverse phase HPLC technique to be highly sensitive, accurate, precise and user-friendly and hence recommend it. Therefore, it could be useful in a quality control lab.
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页码：94 / 100
页数：7
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