Markers of amyloid-β deposition and burden of enlarged perivascular spaces in patients with cognitive impairment and small vessel disease

被引：1

作者：

Costa, Ana Sofia ^{[1
,2
,3
]}

Exalto, Lieza G. ^{[4
]}

van der Flier, Wiesje M. ^{[5
]}

Teunissen, Charlotte E. ^{[6
]}

Barkhof, Frederik ^{[7
,8
,9
]}

Kuijf, Hugo J. ^{[10
,11
]}

Biessels, Geert Jan ^{[4
]}

TRACE-VCI Study Grp

机构：

[1] Univ Hosp RWTH Aachen, Dept Neurol, Aachen, Germany

[2] Res Ctr Juelich, JARA Inst Mol Neurosci & Neuroimaging INM 11, Aachen, Germany

[3] Rhein Westfal TH Aachen, Julich, Germany

[4] Univ Med Ctr Utrecht, Dept Neurol, UMC Utrecht Brain Ctr, POB 85500, NL-3508 GA Utrecht, Netherlands

[5] Amsterdam UMC, Dept Neurol, Alzheimer Ctr Amsterdam, Locat VUmc, Amsterdam, Netherlands

[6] Vrije Univ Amsterdam, Dept Clin Chem, Neurochem Lab, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands

[7] Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Amsterdam Neurosci, Amsterdam UMC, Amsterdam, Netherlands

[8] UCL, Queen Sq Inst Neurol, London, England

[9] UCL, Ctr Med Image Comp, London, England

[10] Univ Med Ctr Utrecht, Image Sci Inst, Utrecht, Netherlands

[11] Univ Utrecht, Utrecht, Netherlands

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2024年 / 102卷 / 04期

关键词：

Alzheimer's disease; amyloid-beta accumulation; cerebral amyloid angiopathy; memory clinic; perivascular spaces; small vessel disease; strictly lobar microbleeds; MRI; ANGIOPATHY;

D O I：

10.1177/13872877241296012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MRI-visible enlarged perivascular spaces (EPVS) are common in patients with cognitive impairment and possibly linked to Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). In a study of memory clinic patients (n = 450; mean age 66.5 +/- 7.45, 45.8% female), we investigated CSF amyloid-beta (A beta)1-42 (AD biomarker) and strictly lobar microbleeds (CAA marker) in relation to centrum semiovale EPVS (CSO-EPVS). Age-controlled analyses showed that severe CSO-EPVS associated with A beta status (odds ratio [OR] = 1.51, 95%CI = 1.02-2.24), but not strictly lobar microbleeds (OR = 1.39, 95%CI = 0.92-2.11), with no significant A beta status and microbleeds interaction. This implies that in this setting, severe CSO-EPVS is not a specific indicator of CAA.

引用

页码：981 / 986

页数：6

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