Distinct role of Klotho in long bone and craniofacial bone: skeletal development, repair and regeneration

被引：3
作者：
Chen, Xinyu [1 ,2 ,3 ]
Wei, Yali [1 ,2 ,3 ,4 ]
Li, Zucen [1 ,2 ,3 ,4 ]
Zhou, Chenchen [1 ,2 ,3 ,5 ]
Fan, Yi [1 ,2 ,3 ,4 ]
机构：
[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu, Peoples R China
[2] Sichuan Univ, West China Hosp Stomatol, Natl Ctr Stomatol, Chengdu, Peoples R China
[3] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu, Peoples R China
[4] Sichuan Univ, West China Hosp Stomatol, Dept Operat Dent & Endodont, Chengdu, Peoples R China
[5] Sichuan Univ, West China Hosp Stomatol, Dept Pediat Dent, Chengdu, Peoples R China
来源：
PEERJ | 2024年 / 12卷
基金：
中国国家自然科学基金;
关键词：
Klotho protein; Bone remodeling; Maxillofacial bone; Appendicular skeleton; Clinical therapy; GROWTH-FACTOR; 23; TRANSCRIPTS ENCODING MEMBRANE; LINEAGE FATE DETERMINATION; MESENCHYMAL STEM-CELLS; TNF-ALPHA; OSTEOCLAST DIFFERENTIATION; KIDNEY-DISEASE; IN-VITRO; EXPRESSION; PROTEIN;
D O I：
10.7717/peerj.18269
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Bone defects are highly prevalent diseases caused by trauma, tumors, inflammation, congenital malformations and endocrine abnormalities. Ideally effective and side effect free approach to dealing with bone defects remains a clinical conundrum. Klotho is an important protein, which plays an essential role in regulating aging and mineral ion homeostasis. More recently, research revealed the function of Klotho in regulating skeleton development and regeneration. Klotho has been identified in mesenchymal stem cells, osteoblasts, osteocytes and osteoclasts in different skeleton regions. The specific function and regulatory mechanisms of Klotho in long bone and craniofacial bone vary due to their different embryonic development, ossification and cell types, which remain unclear and without conclusion. Moreover, studies have confirmed that Klotho is a multifunctional protein that can inhibit inflammation, resist cancer and regulate the endocrine system, which may further accentuate the potential of Klotho to be the ideal molecule in inducing bone restoration clinically. Besides, as an endogenous protein, Klotho has a promising potential for clinical therapy without side effects. In the current review, we summarized the specific function of Klotho in long bone and craniofacial skeleton from phenotype to cellular alternation and signaling pathway. Moreover, we illustrated the possible future clinical application for Klotho. Further research on Klotho might help to solve the existing clinical difficulties in bone healing and increase the life quality of patients with bone injury and the elderly.
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页数：33
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