Urinary tract infections and catheter-associated urinary tract infections caused by Pseudomonas aeruginosa

被引:7
作者
El Husseini, Nour [1 ]
Carter, Jared A. [1 ]
Lee, Vincent T. [1 ]
机构
[1] Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA
基金
美国国家卫生研究院;
关键词
Pseudomonas aeruginosa; catheter-associated urinary tract infection; healthcare-associated infections; virulence factors; animal models; CYCLIC-DI-GMP; GUANINE-NUCLEOTIDE EXCHANGE; GTPASE-ACTIVATING PROTEIN; HEAT-LABILE HEMOLYSIN; EXOENZYME-S; VIRULENCE FACTORS; ADP-RIBOSYLATION; ESCHERICHIA-COLI; BIOFILM FORMATION; FLAGELLIN GENE;
D O I
10.1128/mmbr.00066-22
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Urinary tract infection (UTI) is one of the most common infections in otherwise healthy individuals. UTI is also common in healthcare settings where patients often require urinary catheters to alleviate urinary retention. The placement of a urinary catheter often leads to catheter-associated urinary tract infection (CAUTI) caused by a broad range of opportunistic pathogens, commonly referred to as ESKAPE (Enterococcus, Staphylococcus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter) pathogens. Our understanding of CAUTI is complicated by the differences in pathogens, in initial microbial load, changes that occur due to the duration of catheterization, and the relationship between infection (colonization) and disease symptoms. To advance our understanding of CAUTI, we reviewed UTI and CAUTI caused by Pseudomonas aeruginosa which is unique in that it is not commonly found associated with human microbiomes. For this reason, the ability of P. aeruginosa to cause UTI and CAUTI requires the introduction of the bacteria to the bladder from catheterization. Once in the host, the virulence factors used by P. aeruginosa in these infections remain an area of ongoing research. In this review, we will discuss studies that focus on P. aeruginosa UTI and CAUTI to better understand the infection dynamics and outcome in clinical settings, virulence factors associated with P. aeruginosa isolated from the urinary tract, and animal studies to test which bacterial factors are required for this infection. Understanding how P. aeruginosa can cause UTI and CAUTI can provide an understanding of how these infections initiate and progress and may provide possible strategies to limit these infections.
引用
收藏
页数:42
相关论文
共 217 条
[1]   Efficacy of single and multiple oral doses of fosfomycin against Pseudomonas aeruginosa urinary tract infections in a dynamic in vitro bladder infection model [J].
Abbott, Iain J. ;
van Gorp, Elke ;
Wijma, Rixt A. ;
Dekker, Jordy ;
Croughs, Peter D. ;
Meletiadis, Joseph ;
Mouton, Johan W. ;
Peleg, Anton Y. .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2020, 75 (07) :1879-1888
[2]   Fosfomycin efficacy and emergence of resistance among Enterobacteriaceae in an in vitro dynamic bladder infection model [J].
Abbott, Iain J. ;
Meletiadis, Joseph ;
Belghanch, Imane ;
Wijma, Rixt A. ;
Kanioura, Lamprini ;
Roberts, Jason A. ;
Peleg, Anton Y. ;
Mouton, Johan W. .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2018, 73 (03) :709-719
[3]   XCP-MEDIATED PROTEIN SECRETION IN PSEUDOMONAS-AERUGINOSA - IDENTIFICATION OF 2 ADDITIONAL GENES AND EVIDENCE FOR REGULATION OF XCP GENE-EXPRESSION [J].
AKRIM, M ;
BALLY, M ;
BALL, G ;
TOMMASSEN, J ;
TEERINK, H ;
FILLOUX, A ;
LAZDUNSKI, A .
MOLECULAR MICROBIOLOGY, 1993, 10 (02) :431-443
[4]   ELECTROPHORETIC SEPARATION AND MOLECULAR-WEIGHT CHARACTERIZATION OF PSEUDOMONAS-AERUGINOSA H-ANTIGEN FLAGELLINS [J].
ALLISON, JS ;
DAWSON, M ;
DRAKE, D ;
MONTIE, TC .
INFECTION AND IMMUNITY, 1985, 49 (03) :770-774
[5]   Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections [J].
Andersen, Marissa Jeme ;
Fong, ChunKi ;
La Bella, Alyssa Ann ;
Molina, Jonathan Jesus ;
Molesan, Alex ;
Champion, Matthew M. ;
Howell, Caitlin ;
Flores-Mireles, Ana L. .
ELIFE, 2022, 11
[6]   Prospective assessment of catheter- associated bacteriuria clinical presentation, epidemiology, and colonization dynamics in nursing home residents [J].
Armbruster, Chelsie E. ;
Brauer, Aimee L. ;
Humby, Monica S. ;
Shao, Jiahui ;
Chakraborty, Saptarshi .
JCI INSIGHT, 2021, 6 (19)
[7]   Pseudomonas quinolone signalling system: A component of quorum sensing cascade is a crucial player in the acute urinary tract infection caused by Pseudomonas aeruginosa [J].
Bala, Anju ;
Chhibber, Sanjay ;
Harjai, Kusum .
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2014, 304 (08) :1199-1208
[8]   Pseudomonas aeruginosa Exotoxin Y-Mediated Tau Hyperphosphorylation Impairs Microtubule Assembly in Pulmonary Microvascular Endothelial Cells [J].
Balczon, Ron ;
Prasain, Nutan ;
Ochoa, Cristhiaan ;
Prater, Jason ;
Zhu, Bing ;
Alexeyev, Mikhail ;
Sayner, Sarah ;
Frank, Dara W. ;
Stevens, Troy .
PLOS ONE, 2013, 8 (09)
[9]   PROTEIN SECRETION IN PSEUDOMONAS-AERUGINOSA - CHARACTERIZATION OF 7 XCP GENES AND PROCESSING OF SECRETORY APPARATUS COMPONENTS BY PREPILIN PEPTIDASE [J].
BALLY, M ;
FILLOUX, A ;
AKRIM, M ;
BALL, G ;
LAZDUNSKI, A ;
TOMMASSEN, J .
MOLECULAR MICROBIOLOGY, 1992, 6 (09) :1121-1131
[10]   PROTEIN SECRETION IN PSEUDOMONAS-AERUGINOSA - THE XCPA GENE ENCODES AN INTEGRAL INNER MEMBRANE-PROTEIN HOMOLOGOUS TO KLEBSIELLA-PNEUMONIAE SECRETION FUNCTION PROTEIN PULO [J].
BALLY, M ;
BALL, G ;
BADERE, A ;
LAZDUNSKI, A .
JOURNAL OF BACTERIOLOGY, 1991, 173 (02) :479-486