Terahertz scanning near-field optical microscopy for biomedical detection: Recent advances, challenges, and future perspectives

被引：1
作者：
Yan, Shihan [1 ,2 ,3 ]
Cheng, Guanyin [1 ,2 ,3 ]
Yang, Zhongbo [1 ,2 ,3 ]
Guo, Yuansen [1 ,2 ,3 ]
Chen, Ligang [1 ,2 ,3 ]
Fu, Ying [1 ,2 ,3 ]
Qiu, Fucheng [1 ,2 ,3 ]
Wilksch, Jonathan J. [4 ]
Wang, Tianwu [5 ]
Sun, Yiwen [6 ]
Fan, Junchao [7 ]
Wei, Xunbin [8 ]
Han, Jiaguang [9 ]
Sun, Fei [10 ]
Xu, Shixiang [6 ]
Wang, Huabin [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Ctr Superresolut Opt, Chongqing 400714, Peoples R China
[2] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing Engn Res Ctr High Resolut & Three Dimens, Chongqing 400714, Peoples R China
[3] Univ Chinese Acad Sci, Chongqing Sch, Chongqing 400714, Peoples R China
[4] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic 3000, Australia
[5] Chinese Acad Sci, Aerosp Informat Res Inst, Beijing 100094, Peoples R China
[6] Shenzhen Univ, Coll Phys & Optoelect Engn, Shenzhen 518060, Peoples R China
[7] Chongqing Univ Posts & Telecommun, Coll Comp Sci & Technol, Chongqing Key Lab Image Cognit, Chongqing 400065, Peoples R China
[8] Peking Univ, Biomed Engn Dept, Beijing 100081, Peoples R China
[9] Tianjin Univ, Coll Precis Instrument & Optoelect Engn, Ctr Terahertz Waves, Key Lab Optoelect Informat & Technol,Minist Educ, Tianjin 300072, Peoples R China
[10] Chinese Acad Sci, Inst Biophys, Ctr Biol Imaging, Core Facil Prot Sci, Beijing 100101, Peoples R China
来源：
BIOTECHNOLOGY ADVANCES | 2025年 / 79卷
基金：
中国国家自然科学基金;
关键词：
Terahertz; Scanning near-field optical microscopy; Super resolution; Imaging; Biomedical detection; SPECTROSCOPY; TECHNOLOGY; SCATTERING; RESOLUTION; RADIATION;
D O I：
10.1016/j.biotechadv.2024.108507
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Terahertz (THz) radiation is widely recognized as a non-destructive, label-free, and highly- sensitive tool for biomedical detections. Nevertheless, its application in precision biomedical fields faces challenges due to poor spatial resolution caused by intrinsically long wavelength characteristics. THz scanning near-field optical microscopy (THz-SNOM), which surpasses the Rayleigh criterion, offers micrometer and nanometer-scale spatial resolution, making it possible to perform precise bioinspection with THz imaging. THz-SNOM is attracting considerable attention for its potential in advanced biomedical research and diagnosis. Currently, its family typically includes four members based on distinct principles, which are suitable for different biological applications. This review provides an overview of the principles of these THz-SNOM modalities, outlines their various applications, identifies the obstacles hindering their performance, and envisions their future development.
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页数：14
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