Diethyl Phosphate-Catalyzed One-Pot Synthesis of 2,3-Dihydroquinolin-4(1H)-ones from 2-Aminoacetophenones and Benzaldehydes

被引：0

作者：

He, Lanfeng ^{[1
]}

Wang, Enhua ^{[2
]}

Zheng, Shuang ^{[3
]}

Ban, Yingguo ^{[3
]}

Hou, Kaiping ^{[3
]}

Yang, Lishou ^{[3
]}

Yang, Xiaosheng ^{[3
]}

机构：

[1] Guizhou Univ Tradit Chinese Med, Coll Pharm, Guiyang 550025, Peoples R China

[2] Guizhou Vocat Coll Agr, Dept Food & Med, Guiyang 550041, Peoples R China

[3] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China

来源：

CHEMISTRYSELECT | 2024年 / 9卷 / 43期

基金：

中国国家自然科学基金;

关键词：

2,3-Dihydroquinolin-4(1H)-one; Diethyl phosphate; One-pot synthesis; ASYMMETRIC-SYNTHESIS; CORRESPONDING 2-ARYL-2,3-DIHYDROQUINOLIN-4(1H)-ONES; BIOLOGICAL EVALUATION; EFFICIENT CATALYST; ANTITUMOR AGENTS; DERIVATIVES; CYCLIZATION; 2'-AMINOCHALCONES; LIGANDS; FACILE;

D O I：

10.1002/slct.202404028

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A diethyl phosphate (DEP)-catalyzed one-pot synthesis of 2,3-dihydroquinolin-4(1H)-ones in DMF was achieved. Control experiments led to a plausible mechanism involving an intermolecular aldol condensation of 2-aminoacetophenone and aldehyde, followed by a hydrogen bond-driven cyclization. In this process, a series of 2,3-dihydroquinolin-4(1H)-ones were obtained in good yields (48-84%). This strategy features transition metal-free and short reaction times.

引用

页数：4

共 36 条

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