Engineered Nanocatalyst-Enabled Cheolesterol Depletion for Enhanced Tumor Piezocatalytic Therapy

被引:1
作者
Li, Mengdan [1 ]
Zhou, Yajun [2 ]
Chen, Xiaoyang [1 ]
Chen, Weiwei [1 ]
Yang, Yifei [1 ]
Qian, Cheng [1 ]
Yang, Lei [1 ]
Zhang, Yaohan [1 ]
Zhang, Zheng [3 ]
Wu, Wencheng [4 ,5 ]
Yin, Yifei [1 ]
机构
[1] Nantong Univ, Affiliated Hosp, Med Sch, Dept Med Ultrasound, Nantong 226001, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Affiliated Hosp 4, Dept Ultrasound, Nanjing 210029, Jiangsu, Peoples R China
[3] Jiangsu Univ, Affiliated Hosp, Dept Med Ultrasound, Zhenjiang 212000, Jiangsu, Peoples R China
[4] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Acad Med Sci, Cent Lab, Chengdu 610072, Sichuan, Peoples R China
[5] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Acad Med Sci, Dept Med Ultrasound, Chengdu 610072, Sichuan, Peoples R China
基金
中国国家自然科学基金; 美国国家科学基金会;
关键词
cholesterol depletion; piezocatalytic tumor therapy; reactive oxygen species; tumor antimetastatic; CANCER; MICROENVIRONMENT;
D O I
10.1002/advs.202500967
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The inadequate generation of reactive oxygen species (ROS) and metastasis of malignant tumors are critical factors that limit the efficacy of conventional sonodynamic therapy in cancer treatment. Herein, an engineered piezocatalyst: cholesterol oxidase (CHO)-loaded Pt-ZnO nanoparticles (Pt-ZnO/CHO) that can explosively generate large amounts of ROS and block the metastasis of tumor, is developed for improving piezocatalytic tumor therapy. In this process, Pt-ZnO can substantially generate ROS via initiating ultrasound (US)-triggered piezocatalytic reactions. In situ-grown Pt nanoparticles not only optimize piezocatalytic activities but also facilitate oxygen (O2) production, thereby synergistically boosting ROS generation. Moreover, O2 produced by Pt-ZnO can accelerate the depletion of excess cholesterol in tumor cells under CHO catalysis to disrupt the integrity of lipid rafts and inhibit the formation of lamellipodia, significantly suppressing the proliferation and metastasis of tumor cells. This strategy by promoting ROS generation and blocking the metastatic pathway of cancer cells offers a new idea for enhanced efficacy-oriented cancer therapeutic strategies.
引用
收藏
页数:11
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