Preoperative systemic immune-inflammation index as a predictor of contrast-induced acute kidney injury in coronary artery disease: a multicenter cohort study

被引：0

作者：

Zhu, Jinlong ^{[1
,2
]}

Yu, Pei ^{[1
,2
]}

Zhang, Xiaoying ^{[1
,2
]}

Li, Xiaoming ^{[1
,2
]}

Huang, Jiaming ^{[1
,2
]}

Zhao, Shumin ^{[1
,2
]}

Ruan, Qingyan ^{[1
,2
]}

He, Yibo ^{[3
]}

Zhou, Yang ^{[3
]}

Bao, Kunming ^{[1
]}

Xiu, Jiaming ^{[1
]}

Deng, Lin ^{[1
,2
]}

Liu, Yunchen ^{[1
,2
]}

Liu, Yong ^{[3
]}

Chen, Shiqun ^{[4
]}

Chen, Kaihong ^{[1
]}

Chen, Liling ^{[1
]}

机构：

[1] Fujian Med Univ, Longyan Affiliated Hosp 1, Dept Cardiol, Longyan, Peoples R China

[2] Fujian Med Univ, Clin Med Coll 3, Fuzhou, Peoples R China

[3] Southern Med Univ, Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst,Dept Guangdong Prov Key, Guangzhou, Peoples R China

[4] Southern Med Univ, Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Global Hlth Res Ctr, Guangzhou, Peoples R China

来源：

RENAL FAILURE | 2025年 / 47卷 / 01期

关键词：

Acute kidney injury; contrast-induced acute kidney injury; systemic immune-inflammation index; coronary artery disease; nonlinear relationship; biomarker; C-REACTIVE PROTEIN; INDUCED NEPHROPATHY; RISK; INTERVENTION; ACTIVATION; UNDERWENT; MORTALITY; ELEVATION; MODEL;

D O I：

10.1080/0886022X.2025.2474204

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background Inflammation is a key contributor to contrast-induced acute kidney injury (CI-AKI), yet its predictive role remains unclear. The systemic immune-inflammation index (SII) is a novel inflammatory biomarker, but its association with CI-AKI risk in coronary artery disease (CAD) patients undergoing coronary angiography is not well established. This study aimed to evaluate the relationship between preoperative SII and CI-AKI in a large multicenter cohort. Methods This retrospective cohort study analyzed CAD patients from five tertiary hospitals in China (2007-2020). Patients were stratified into SII tertiles, and multivariable logistic regression, restricted cubic splines (RCS), and two-piecewise logistic regression models were employed to assess the association between SII and CI-AKI risk. Results Among 30,822 patients, 3,246 (10.5%) developed CI-AKI. Higher preoperative SII levels were associated with increased CI-AKI risk ([SII-M vs. SII-L]: OR = 1.22, 95% CI [1.09-1.36], p = 0.001; [SII-H vs. SII-L]: OR = 1.70, 95% CI [1.53-1.90], p < 0.001). RCS analysis demonstrated a nonlinear relationship (p for nonlinearity = 0.008). The inflection point was at 19.12 x 10(11)/L. Below this inflection point, each 100-unit increase in SII correlated with a 5% higher CI-AKI risk (OR = 1.05, 95% CI [1.04-1.06], p < 0.001), while no significant association was observed above this level. Conclusion Preoperative SII may be an independent predictor of CI-AKI risk in CAD patients undergoing undergoing coronary angiography, demonstrating a nonlinear dose-response relationship with a significant threshold effect. These findings suggest that SII may serve as a useful biomarker for early CI-AKI risk stratification in clinical practice.

引用

页数：11

共 49 条

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