Lymph node assessment in cervical cancer: current approaches

被引:0
作者
Dheur, Adriane [1 ]
Kakkos, Athanasios [1 ]
Danthine, Denis [2 ]
Delbecque, Katty [3 ]
Goffin, Frederic [1 ]
Gonne, Elodie [4 ]
Lovinfosse, Pierre [5 ]
Pleyers, Clemence [6 ]
Thille, Alain [2 ]
Kridelka, Frederic [1 ]
Gennigens, Christine [4 ]
机构
[1] CHU Liege, Univ Hosp Liege, Dept Gynecol & Obstet, Liege, Belgium
[2] CHU Liege, Univ Hosp Liege, Dept Radiol, Liege, Belgium
[3] CHU Liege, Univ Hosp Liege, Dept Pathol, Liege, Belgium
[4] CHU Liege, Univ Hosp Liege, Dept Med Oncol, Liege, Belgium
[5] CHU Liege, Univ Hosp Liege, Dept Nucl Med & Oncol Imaging, Liege, Belgium
[6] CHU Liege, Univ Hosp Liege, Dept Radiotherapy, Liege, Belgium
来源
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词
cervical cancer; lymph node assessment; sentinel lymph node; imaging modalities; surgical staging; LAPAROSCOPIC PARAAORTIC LYMPHADENECTOMY; POSITRON-EMISSION-TOMOGRAPHY; FROZEN-SECTION EXAMINATION; FALSE-NEGATIVE RATE; ENDOMETRIAL CANCER; PET-CT; MULTICENTER; METASTASES; DISSECTION; TRIAL;
D O I
10.3389/fonc.2024.1435532
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cervical cancer (CC) is the fourth most common neoplasia in women worldwide. Although early-stage CC is often curable, 40 to 50% of patients are diagnosed at a locally advanced stage. Metastatic disease accounts for the principal cause of death. Lymph node (LN) status is a major factor impacting treatment options and prognosis. Historically, CC was staged based only on clinical findings. However, in 2018, imaging modalities and/or pathological findings were included in the International Federation of Gynecology and Obstetrics (FIGO) staging classification. In the last decades, LN status assessment has evolved considerably. Full pelvic lymphadenectomy used to be the only way to determine LN status. Currently, several options exist: surgery with full lymphadenectomy, sentinel lymph node (SLN) biopsy or imaging modalities such as computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET). Regarding surgery, the SLN biopsy technique has become a standard procedure in cases of CC, with indocyanine green (ICG) being the preferred dye. Pelvic MRI is a valuable imaging technique modality for the evaluation of pelvic LNs. In locally advanced or in early-stage disease with suspicious LNs on CT scans or MRI, PET/CT is recommended for assessment of nodal and distant status. The best strategy for LN assessment remains a highly controversial topic in the literature. In this article, we aim to review and compare the advantages and limitations of each modality, i.e. imaging or surgical (lymphadenectomy or SLN biopsy) approaches.
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页数:10
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