Considerations on Multimorbidity and Frailty in Inflammatory Bowel Diseases

被引:1
作者
Carbery, Isabel [1 ]
Selinger, Christian P. [2 ]
Todd, Oliver [2 ]
Sebastian, Shaji [3 ]
机构
[1] Leeds Teaching Hosp NHS Trust, Leeds Gastroenterol Inst, Leeds, England
[2] Univ Leeds, Bradford Inst Hlth Res, Acad Unit Ageing & Stroke Res, Bradford, England
[3] Hull Univ Teaching Hosp, IBD Unit, Kingston Upon Hull, England
关键词
Ageing; frailty; IBD; DRUG-TREATMENT PRACTICES; ANTI-TNF THERAPY; ELDERLY-PATIENTS; OLDER-ADULTS; SERIOUS INFECTIONS; ULCERATIVE-COLITIS; CROHNS-DISEASE; INCREASED RISK; PREVALENCE; OUTCOMES;
D O I
10.1093/ecco-jcc/jjae067
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
There are growing numbers of older people with inflammatory bowel diseases [IBD]. These older patients are more likely to have other comorbidities and polypharmacy, which can make recognizing and treating IBD complex. Frailty is a newer concept in the IBD field, and we are beginning to recognize the importance of this as a marker of biological age and its association with risk of adverse IBD-related outcomes. In this review article we aim to provide practical insight into the specific challenges facing older patients and their clinicians at each stage of the patient journey. We also discuss the latest understanding of the impact of frailty for these patients with IBD and highlight areas for future research.
引用
收藏
页码:ii46 / ii54
页数:9
相关论文
共 107 条
[1]   Comparative safety and effectiveness of tumor necrosis factor α antagonists and vedolizumab in elderly IBD patients: a multicentre study [J].
Adar, Tomer ;
Faleck, David ;
Sasidharan, Saranya ;
Cushing, Kelly ;
Borren, Nienke Z. ;
Nalagatla, Niharika ;
Ungaro, Ryan ;
Sy, Wayne ;
Owen, Samuel C. ;
Patel, Anish ;
Cohen, Benjamin L. ;
Ananthakrishnan, Ashwin N. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2019, 49 (07) :873-879
[2]   Do Thiopurines Reduce the Risk of Surgery in Elderly Onset Inflammatory Bowel Disease? A 20-Year National Population-Based Cohort Study [J].
Alexakis, Christopher ;
Saxena, Sonia ;
Chhaya, Vivek ;
Cecil, Elizabeth ;
Curcin, Vasa ;
Pollok, Richard .
INFLAMMATORY BOWEL DISEASES, 2017, 23 (04) :672-680
[3]   Vedolizumab does not increase risk of clostridium difficile infection in patients with inflammatory bowel disease using vedolizumab: A retrospective cohort study [J].
Alshahrani, Abdulaziz Saad ;
Mohammad, Danah ;
Alzahrani, Mohammad Attieh ;
Narula, Neeraj .
SAUDI PHARMACEUTICAL JOURNAL, 2023, 31 (09)
[4]   Management of Inflammatory Bowel Disease in the Elderly Patient: Challenges and Opportunities [J].
Ananthakrishnan, Ashwin N. ;
Donaldson, Tamara ;
Lasch, Karen ;
Yajnik, Vijay .
INFLAMMATORY BOWEL DISEASES, 2017, 23 (06) :882-893
[5]  
[Anonymous], 2020, World population ageing 2020 highlights: Living arrangements of older persons
[6]   Deficits in Geriatric Assessment Associate With Disease Activity and Burden in Older Patients With Inflammatory Bowel Disease [J].
Asscher, Vera E. R. ;
Waars, Sanne N. ;
Van Der Meulen-de Jong, Andrea E. ;
Stuyt, Rogier J. L. ;
Baven-Pronk, A. Martine C. ;
van Der Marel, Sander ;
Jacobs, Rutger J. ;
Haans, Jeoffrey J. L. ;
Meijer, Lennart J. ;
Klijnsma-Slagboom, Jacqueline D. ;
Duin, Marijn H. ;
Peters, Milou E. R. ;
Lee-Kong, Felicia V. Y. L. ;
Provoost, Nanda E. ;
Tijdeman, Femke ;
van Dijk, Kenan T. ;
Wieland, Monse W. M. ;
Verstegen, Mirre G. M. ;
van Der Meijs, Melissa E. ;
Maan, Annemijn D., I ;
van Deudekom, Floor J. ;
Mooijaart, Simon P. ;
Maljaars, P. W. Jeroen .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2022, 20 (05) :E1006-E1021
[7]   Diagnosis and Treatment of Clostridium difficile in Adults A Systematic Review [J].
Bagdasarian, Natasha ;
Rao, Krishna ;
Malani, Preeti N. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2015, 313 (04) :398-408
[8]   Screening older cancer patients: first evaluation of the G-8 geriatric screening tool [J].
Bellera, C. A. ;
Rainfray, M. ;
Mathoulin-Pelissier, S. ;
Mertens, C. ;
Delva, F. ;
Fonck, M. ;
Soubeyran, P. L. .
ANNALS OF ONCOLOGY, 2012, 23 (08) :2166-2172
[9]   Increased Postoperative Mortality and Complications Among Elderly Patients With Inflammatory Bowel Diseases: An Analysis of the National Surgical Quality Improvement Program Cohort [J].
Bollegala, Natasha ;
Jackson, Timothy D. ;
Nguyen, Geoffrey C. .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2016, 14 (09) :1274-1281
[10]   Safety of Biologic Therapy in Older Patients With Immune-Mediated Diseases: A Systematic Review and Meta-analysis [J].
Borren, Nienke Z. ;
Ananthakrishnan, Ashwin N. .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2019, 17 (09) :1736-+