Exploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium

被引：0

作者：

Elyaman, Wassim ^{[1
,2
,3
,4
]}

Stern, Lawrence J. ^{[5
]}

Jiang, Ning ^{[6
]}

Dressman, Dallin ^{[1
,2
,3
,4
]}

Bradley, Philip ^{[7
]}

Klatzmann, David ^{[8
]}

Bradshaw, Elizabeth M. ^{[1
,2
,3
,4
,9
]}

Farber, Donna L. ^{[10
]}

Kent, Sally C. ^{[11
]}

Chizari, Shahab ^{[6
]}

Funk, Kristen ^{[12
]}

Devanand, Davangere ^{[13
]}

Thakur, Kiran T. ^{[4
]}

Raj, Towfique ^{[14
]}

Dalahmah, Osama Al ^{[15
]}

Sarkis, Rani A. ^{[16
]}

Weiner, Howard L. ^{[17
]}

Shneider, Neil A. ^{[3
,4
,18
]}

Przedborski, Serge ^{[3
,4
]}

机构：

[1] Columbia Univ Med Ctr, Dept Neurol, Div Translat Neurobiol, 630W 168th St, New York, NY 10032 USA

[2] Columbia Univ, Med Ctr, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10027 USA

[3] Columbia Univ, Med Ctr, Ctr Motor Neuron Biol & Dis, New York, NY USA

[4] Columbia Univ, Med Ctr, Dept Neurol, New York, NY USA

[5] UMass Chan Med Sch, Dept Pathol, Immunol & Microbiol Program, Worcester, MA USA

[6] Univ Penn, Abramson Canc Ctr, Ctr Cellular Immunotherapies, Philadelphia, PA 19104 USA

[7] Fred Hutchinson Canc Ctr, Computat Biol Program, Publ Hlth Sci Div, Seattle, WA USA

[8] Sorbonne Univ, INSERM UMRS 959, Immunol Immunopathol Immunotherapy I3, Paris, France

[9] Columbia Univ, Carol & Gene Ludwig Ctr Res Neurodegenerat, Irving Med Ctr, New York, NY 10032 USA

[10] Columbia Univ, Dept Surg, New York, NY 10032 USA

[11] Univ Massachusetts, Chan Med Sch, Dept Med, Diabet Ctr Excellence, Worcester, MA USA

[12] Univ North Carolina Charlotte, Dept Biol Sci, Charlotte, NC USA

[13] Columbia Univ, Med Ctr, Dept Psychiat, New York, NY USA

[14] Icahn Sch Med Mt Sinai, Icahn Inst Data Sci & Genom Technol, Dept Genet & Genom Sci, New York, NY USA

[15] Columbia Univ, Irving Med Ctr, Vagelos Coll Phys & Surg, New York Presbyterian Hosp, New York, NY USA

[16] Harvard Med Sch, Brigham & Womens Hosp, Dept Neurol, Epilepsy Div, Boston, MA USA

[17] Harvard Med Sch, Brigham & Womens Hosp, Ann Romney Ctr Neurol Dis, Boston, MA USA

[18] Columbia Univ, Eleanor & Lou Gehrig ALS Ctr, New York, NY USA

来源：

ALZHEIMERS & DEMENTIA | 2025年 / 21卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; amyotrophic lateral sclerosis; brain; central nervous system; clinical trials; conference proceedings; epilepsy; immunotherapy; major histocompatibility complex peptidome; Parkinson's disease; single-cell RNA sequencing; spinal cord; T cell receptor repertoire; T cells; viral infection;

D O I：

10.1002/alz.14548

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This proceedings article summarizes the inaugural "T Cells in the Brain" symposium held at Columbia University. Experts gathered to explore the role of T cells in neurodegenerative diseases. Key topics included characterization of antigen-specific immune responses, T cell receptor (TCR) repertoire, microbial etiology in Alzheimer's disease (AD), and microglia-T cell crosstalk, with a focus on how T cells affect neuroinflammation and AD biomarkers like amyloid beta and tau. The symposium also examined immunotherapies for AD, including the Valacyclovir Treatment of Alzheimer's Disease (VALAD) trial, and two clinical trials leveraging regulatory T cell approaches for multiple sclerosis and amyotrophic lateral sclerosis therapy. Additionally, single-cell RNA/TCR sequencing of T cells and other immune cells provided insights into immune dynamics in neurodegenerative diseases. This article highlights key findings from the symposium and outlines future research directions to further understand the role of T cells in neurodegeneration, offering innovative therapeutic approaches for AD and other neurodegenerative diseases. Highlights Researchers gathered to discuss approaches to study T cells in brain disorders. New technologies allow high-throughput screening of antigen-specific T cells. Microbial infections can precede several serious and chronic neurological diseases. Central and peripheral T cell responses shape neurological disease pathology. Immunotherapy can induce regulatory T cell responses in neuroinflammatory disorders.

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页数：11

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