Incidence and Prognosis of Prosthesis-Patient Mismatch After Transcatheter Aortic Valve Replacement for Bicuspid Aortic Stenosis

被引：2

作者：

Yamanaka, Futoshi ^{[1
]}

Shishido, Koki ^{[1
]}

Moriyama, Noriaki ^{[1
]}

Ochiai, Tomoki ^{[1
]}

Miyashita, Hirokazu ^{[1
]}

Yokoyama, Hiroaki ^{[1
]}

Sugiyama, Yoichi ^{[1
]}

Yashima, Fumiaki ^{[2
]}

Ohno, Yohei ^{[3
]}

Nishina, Hidetaka ^{[4
]}

Izumo, Masaki ^{[5
]}

Asami, Masahiko ^{[6
]}

Naganuma, Toru ^{[7
]}

Mizutani, Kazuki ^{[8
]}

Yamawaki, Masahiro ^{[9
]}

Tada, Norio ^{[10
]}

Shirai, Shinichi ^{[11
]}

Noguchi, Masahiko ^{[12
]}

Ueno, Hiroshi ^{[13
]}

Takagi, Kensuke ^{[14
]}

Watanabe, Yusuke ^{[15
]}

Yamamoto, Masanori ^{[16
,17
,18
]}

Saito, Shigeru ^{[1
]}

Hayashida, Kentaro ^{[19
]}

机构：

[1] Shonan Kamakura Gen Hosp, Dept Cardiol, Okamoto 1370-1, Kamakura 2478533, Japan

[2] Saiseikai Utsunomiya Hosp, Dept Cardiol, Utsunomiya, Tochigi, Japan

[3] Tokai Univ, Sch Med, Dept Cardiol, Isehara, Japan

[4] Tsukuba Med Ctr Hosp, Dept Cardiol, Tsukuba, Japan

[5] St Marianna Univ, Dept Cardiol, Kawasaki, Japan

[6] Mitsui Mem Hosp, Div Cardiol, Tokyo, Japan

[7] New Tokyo Hosp, Dept Cardiol, Matsudo, Japan

[8] Kindai Univ, Fac Med, Div Cardiol, Higashiosaka, Osaka, Japan

[9] Saiseikai Yokohama City Eastern Hosp, Dept Cardiol, Yokohama, Japan

[10] Sendai Kousei Hosp, Dept Cardiol, Sendai, Japan

[11] Kokura Mem Hosp, Dept Cardiol, Kokura, Japan

[12] Tokyo Bay Urayasu Ichikawa Med Ctr, Dept Cardiol, Urayasu, Japan

[13] Toyama Univ, Dept Pediat, Toyama 9300194, Japan

[14] Natl Cerebral & Cardiovasc Ctr, Dept Cardiol, Osaka, Japan

[15] Teikyo Univ, Sch Med, Dept Cardiol, Tokyo, Japan

[16] Toyohashi Heart Ctr, Dept Cardiol, Toyohashi, Japan

[17] Nagoya Heart Ctr, Dept Cardiol, Nagoya, Japan

[18] Gifu Heart Ctr, Dept Cardiol, Gifu, Japan

[19] Keio Univ, Sch Med, Dept Cardiol, Tokyo, Japan

来源：

JACC-CARDIOVASCULAR INTERVENTIONS | 2025年 / 18卷 / 04期

关键词：

all-cause mortality; bicuspid aortic valve; long-term mortality; prosthesis- patient mismatch; transcatheter aortic valve replacement; OUTCOMES; CLASSIFICATION; ASSOCIATION; IMPACT; TAVI;

D O I：

10.1016/j.jcin.2024.10.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND Evidence regarding the incidence of prosthesis-patient mismatch (PPM) and long-term mortality after transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valve stenosis (AS) is scarce. OBJECTIVES This study sought to assess the incidence and prognostic impact of PPM after TAVR for bicuspid AS compared with that for tricuspid AS. METHODS In total, 7,393 patients who underwent TAVR were prospectively enrolled in the OCEAN-TAVI (Optimized Catheter Valvular Intervention Transcatheter Aortic Valve Implantation) registry, an ongoing Japanese, multicenter registry. We analyzed 7,051 patients (median age = 85 years, 68.4% women) and identified 503 (7.1%) with bicuspid AS. We compared the incidence of PPM and long-term mortality in 497 patients with and 497 without bicuspid AS after oneto-one propensity score matching analysis. RESULTS Among the 7,051 patients, moderate and severe PPM were observed in 756 (10.7%) and 92 (1.3%) patients, respectively. Upon Kaplan-Meier curve analysis of the overall cohort, severe PPM appeared to be associated with longterm mortality (log-rank test, P = 0.065). After propensity score matching analysis, moderate and severe PPM were more frequently observed among patients with tricuspid AS than patients with bicuspid AS (moderate PPM, 11.7% vs 4.4%; severe PPM, 1.4% vs 1.0%; P = 0.0001). CONCLUSIONS Severe PPM appeared to be associated with all-cause mortality. Moderate and severe PPM were more frequently observed in patients with tricuspid AS than patients with bicuspid AS. (JACC Cardiovasc Interv. 2025;18:492-502) (c) 2025 by the American College of Cardiology Foundation.

引用

页码：492 / 502

页数：11

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