The Genetic and Epigenetic Arms of Human Ageing and Longevity

被引：0
|
作者：
Ciaglia, Elena [1 ,2 ]
Montella, Francesco [1 ]
Lopardo, Valentina [1 ]
Basile, Cristina [1 ]
Esposito, Roberta Maria [1 ]
Maglio, Clara [1 ]
Longo, Roberta [1 ]
Maciag, Anna [2 ]
Puca, Annibale Alessandro [1 ,2 ]
机构：
[1] Univ Salerno, Dept Med Surg & Dent Scuola Med Salernitana, Mol & Clin Pathophysiol Lab, Via Salvatore Allende, I-84081 Baronissi, Italy
[2] IRCCS, Cardiovasc Res Unit, Multimed, I-20138 Milan, Italy
来源：
BIOLOGY-BASEL | 2025年 / 14卷 / 01期
关键词：
prolonged lifespan; genes; epigenetic changes; LIFE-STYLE; MECHANISMS; EXPRESSION; NUTRITION; SPAN;
D O I：
10.3390/biology14010092
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
This proposed review aims to shed light on the major genetic and epigenetic contributions to the ageing process and longevity of individuals. In this context, we summarize the state of knowledge on the most important longevity and ageing genetic variants, and their interactions with the environment, in achieving a healthy lifespan. We also explore the contribution of lifestyle and the influence of non-heritable environmental factors on ageing (i.e., epigenetics). Accordingly, we discuss the role of inflammageing as one of the major targets to overcome morbidity and mortality in older people for the maintenance of healthy ageing. This more integrated view of longevity will display not only the underlying mechanisms at play but also invites the reader to rethink both our ageing process and our attitudes toward age.
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页数：17
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