A comprehensive review of caffeine population pharmacokinetics in preterm infants: Factors affecting clearance

被引：0
作者：
He, Yaodong [1 ,2 ]
Shen, Xianhuan [1 ]
Zhu, Jiahao [1 ]
Zhang, Lian [1 ]
Wang, Xixuan [1 ,2 ]
Zhou, Tao [1 ]
Zhang, Jianping [2 ]
Li, Wenzhou [1 ]
Fan, Xiaomei [1 ]
机构：
[1] Shenzhen Baoan Womens & Childrens Hosp, Dept Pharm, Shenzhen 518102, Guangdong, Peoples R China
[2] Jinan Univ, Coll Pharm, Dept Clin Pharmacol, Guangzhou 510632, Guangdong, Peoples R China
来源：
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2025年 / 208卷
关键词：
Population pharmacokinetics; Caffeine; Preterm infant; Clearance; Individualized dosing regimen; DRIED BLOOD SPOTS; PLASMA; APNEA; ERYTHROPOIETIN; INTOLERANCE;
D O I：
10.1016/j.ejpb.2025.114659
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Caffeine is an FDA-approved drug for preventing and treating apnea in preterm infants. However, the pharmacokinetic (PK) characteristics of caffeine in preterm infants differ significantly from those in adults. Several population pharmacokinetic (PopPK) models have been developed to investigate potential covariates influencing PK parameters. This review aimed to summarize PopPK studies of caffeine in preterm infants and explore the identified influencing covariates. It has been observed that most caffeine pharmacokinetics followed a onecompartment model (1-CMT), although one study utilized a three-compartment model (3-CMT). Various covariates including birth weight, current weight, genetic polymorphism, combination medications, feeding patterns, and pathological conditions have been identified to affect caffeine PK parameters in preterm infants. Developing an individualized dosing regimen for preterm infants is essential for safe and effective treatment. Future PopPK studies of caffeine in preterm infants should focus on sampling and feeding patterns and further explore the effects of other covariates like gestational and postnatal age on caffeine PK parameters, which should be taken into account in the individualized dosing regimen of caffeine.
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页数：9
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  • [21] Guo A., Zhu Z., Xue J., Et al., Population pharmacokinetic study of caffeine citrate in Chinese premature infants with apnea, J. Clin. Pharm. Ther., 45, 6, pp. 1414-1421, (2020)
  • [22] Gao X.B., Zheng Y., Yang F., Et al., Developmental population pharmacokinetics of caffeine in Chinese premature infants with apnoea of prematurity: a post-marketing study to support paediatric labelling in China, Br. J. Clin. Pharmacol., 87, 3, pp. 1155-1164, (2021)
  • [23] Thompson E.J., Zimmerman K.O., Gonzalez D., Et al., Population pharmacokinetics of caffeine in neonates with congenital heart disease and associations with acute kidney injury, J Clin Pharmacol., 64, 3, pp. 300-311, (2024)
  • [24] Engbers A.G.J., Voller S., Poets C.F., Et al., The pharmacokinetics of caffeine in preterm newborns: no influence of doxapram but important maturation with age, Neonatology, 118, 1, pp. 106-113, (2021)
  • [25] Dobson N.R., Liu X., Rhein L.M., Et al., Salivary caffeine concentrations are comparable to plasma concentrations in preterm infants receiving extended caffeine therapy, Br. J. Clin. Pharmacol., 82, 3, pp. 754-761, (2016)
  • [26] Lim M.S., Son M.J., Shin J.E., Et al., Clinical pharmacokinetics of caffeine in korean preterm infants with apnea of prematurity, Neonatal Med., 24, 21, pp. 20-25, (2017)
  • [27] Patel P., Mulla H., Kairamkonda V., Et al., Dried blood spots and sparse sampling: a practical approach to estimating pharmacokinetic parameters of caffeine in preterm infants, Br. J. Clin. Pharmacol., 75, 3, pp. 805-813, (2013)
  • [28] Li X.L., Cai Y.J., Zhang Z., Et al., Effect of different maintenance doses of caffeine citrate on ventilator weaning in very preterm infants with respiratory distress syndrome: a prospective randomized controlled trial, Zhongguo Dang Dai Er Ke Za Zhi., 23, 11, pp. 1097-1102, (2021)
  • [29] Sugino M., Kuboi T., Noguchi Y., Et al., Serum caffeine concentrations in preterm infants: a retrospective study, Sci Rep., 13, 1, (2023)
  • [30] Aranda J.V., Gorman W., Bergsteinsson H., Et al., Efficacy of caffeine in treatment of apnea in the low-birth-weight infant, J Pediatr., 90, 3, pp. 467-472, (1977)
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