Stem Cell-Based Therapies for Glaucoma Treatment: A Review Bridging the Gap in Veterinary Patients

被引:0
作者
Moreira, Alicia de Sousa [1 ,2 ,3 ]
Lopes, Bruna [1 ,2 ,3 ]
Sousa, Ana Catarina [1 ,2 ,3 ]
Coelho, Andre [1 ,2 ,3 ]
Sousa, Patricia [1 ,2 ,3 ]
Araujo, Ana [2 ,3 ]
Delgado, Esmeralda [3 ,4 ]
Alvites, Rui [1 ,2 ,3 ,5 ]
Mauricio, Ana Colette [1 ,2 ,3 ]
机构
[1] Univ Porto, Ctr Estudos Ciencia Anim CECA, Inst Ciencias Tecnol & Agroambiente ICETA, Praca Gomes Teixeira,Apartado 55142, P-4051401 Porto, Portugal
[2] Univ Porto UP, Inst Ciencias Biomed Abel Salazar ICBAS, Dept Clin Vet, Rua Jorge Viterbo Ferreira,N 228, P-4050313 Porto, Portugal
[3] Univ Lisboa UL, Associate Lab Anim & Vet Sci AL4AnimalS, Fac Med Vet FMV, Ave Univ Tecn, P-1300477 Lisbon, Portugal
[4] Univ Lisboa UL, Fac Med Vet FMV, Ctr Invest Interdisciplinar Sanidade Anim CIISA, Ave Univ Tecn, P-1300477 Lisbon, Portugal
[5] Inst Univ Ciencias Saude CESPU, Ave Cent Gandra N 1317, P-4585116 Paredes, Portugal
关键词
glaucoma; stem cell-based therapies; mesenchymal stem cells; secretome; umbilical cord mesenchymal stem cells; regenerative medicine; veterinary ophthalmology; veterinary medicine; OPTIC-NERVE DISEASES; OPEN-ANGLE GLAUCOMA; INTRAOCULAR-PRESSURE; OPHTHALMOLOGY TREATMENT; NITRIC-OXIDE; CATARACT-SURGERY; FACTOR SECRETION; CLINICAL-TRIALS; ADIPOSE-TISSUE; STROMAL CELLS;
D O I
10.3390/ijms26010232
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Retinal diseases are characterized by progressive damage to retinal cells, leading to irreversible vision loss. Among these, glaucoma stands out as a multifactorial neurodegenerative disease involving elevated intraocular pressure, retinal ganglion cell apoptosis, and optic nerve damage, ultimately resulting in blindness in both humans and dogs. Stem cell-based therapies have emerged as a promising therapeutic option for such conditions due to their regenerative and neuroprotective potential. These therapies, particularly those based on mesenchymal stem cells, offer the potential to repair and protect retinal tissues through the bioactive molecules (growth factors, cytokines, chemokines) secreted, their secretome. However, research in this field, especially on the use of umbilical cord mesenchymal stem cells' secretome, remains sparse. Most clinical trials focus on human glaucomatous patients, leaving a significant gap in veterinary patients' application, especially in dogs, with additional research being needed to determine its usefulness in canine glaucoma treatment. Future studies should aim to evaluate these therapies across both human and veterinary contexts, broadening treatment possibilities for glaucoma.
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页数:22
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