The role of imbalanced CD226/TIGIT on activated peripheral double-negative T cells in the pathogenesis of primary Sjögren's syndrome

被引：0

作者：

Deng, Chuiwen ^{[1
,2
,3
,4
]}

Wang, Anqi ^{[1
,2
,3
,4
]}

Li, Wenli ^{[5
]}

Chen, Yingying ^{[1
,2
,3
,4
]}

Li, Rongli ^{[1
,2
,3
,4
]}

Zhao, Lidan ^{[1
,2
,3
,4
]}

Zhou, Jiaxin ^{[1
,2
,3
,4
]}

Zhang, Wen ^{[1
,2
,3
,4
]}

Li, Mengtao ^{[1
,2
,3
,4
]}

Zhao, Yan ^{[1
,2
,3
,4
]}

Zeng, Xiaofeng ^{[1
,2
,3
,4
]}

Fei, Yunyun ^{[1
,2
,3
,4
,6
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, Beijing, Peoples R China

[2] Minist Sci & Technol, Natl Clin Res Ctr Dermatol & Immunol Dis NCRC DID, Beijing, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, State Key Lab Complex Severe & Rare Dis, Beijing, Peoples R China

[4] Minist Educ, Key Lab Rheumatol & Clin Immunol, Beijing, Peoples R China

[5] China Japan Friendship Hosp, Dept Rheumatol, Key Myositis Labs, Beijing, Peoples R China

[6] Peking Union Med Coll & Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Hlth Med, Beijing 100010, Peoples R China

来源：

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 2024年 / 42卷 / 12期

基金：

中国国家自然科学基金;

关键词：

double-negative T cell; primary Sj & ouml; gren's syndrome; CD226; TIGIT; CD107a; PRIMARY SJOGRENS-SYNDROME; ASSOCIATION; LYMPHOCYTES; SIGNATURES; INFILTRATE; BLOOD; CD8;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective To explore whether the balance of CD226 and TIGIT is disturbed in CD3+CD56-TCR alpha beta+CD4-CD8-(DN) T cells and have a better understanding of the potential role of DN T cells in the pathogenesis of primary Sj & ouml;gren's syndrome (pSS). Methods The percentage of DN T cells as well as the expression of CD226 and TIGIT was identified by flowmetry. After in vitro stimulation, we further detected the expression of activation and cytotoxic marker, as well as intracellular cytokines secreted by DN T cells. Results DN T cells were found to expand in the peripheral blood of pSS patients (1.77 +/- 0.66%) and correlate with IgG (r=0.451, p<0.05), C3 (r=-0.438, p<0.05) and C4 (r=-0.470, p<0.05). Imbalanced CD226/TIGIT was observed on peripheral DN T cells of pSS patients, especially the overexpression of inhibitory immunoreceptor TIGIT. The expression ratio of TIGIT and CD226 on DN T cells was elevated in pSS patients and correlated with ESSDAI scores >= 5 (r=0.743, p<0.05). Besides, these DN T cells were found to be activated and show strong cytotoxicity. Conclusion The balance between CD226 and TIGIT on DN T cells was disturbed and correlated with the disease activity in pSS patients, which may be implicated in the pathogenesis of pSS.

引用

页码：2369 / 2377

页数：9

共 34 条

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