A specific serum lipid signature characterizes patients with glycogen storage disease type Ia

被引:2
作者
Rossi, Alessandro [1 ,2 ]
Ruoppolo, Margherita [3 ,4 ]
Fedele, Roberta [4 ]
Pirozzi, Francesca [3 ]
Rosano, Carmen [1 ]
Auricchio, Renata [1 ]
Melis, Daniela [5 ]
Strisciuglio, Pietro [1 ]
Oosterveer, Maaike H. [6 ]
Derks, Terry G. J. [2 ]
Parenti, Giancarlo [1 ,7 ]
Caterino, Marianna [3 ,4 ]
机构
[1] Univ Naples Federico II, Dept Translat Med, Sect Pediat, Naples, Italy
[2] Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Sect Metab Dis, Groningen, Netherlands
[3] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, Naples, Italy
[4] CEINGE Biotecnol Avanzate sc ar l, Naples, Italy
[5] Univ Salerno, Dept Med Surg & Dent Scuola Med Salernitana, Salerno, Italy
[6] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat & Lab Med, Groningen, Netherlands
[7] Telethon Inst Genet & Med, Pozzuoli, Italy
关键词
hyperlipidemia; serum lipidome; ceramides; bile acids; lysophosphatidylcholine; HYPERLIPIDEMIA; LIPOGENESIS; MANAGEMENT; RESISTANCE;
D O I
10.1016/j.jlr.2024.100651
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glycogen storage disease type Ia (GSDIa) is a rare, inherited glucose-6-phosphatase-alpha (G6Pase-alpha) deficiency-induced carbohydrate metabolism disorder. Although hyperlipidemia is a hallmark of GSDI, the extent of lipid metabolism disruption remains incompletely understood. Lipidomic analysis was performed to characterize the serum lipidome in patients with GSDIa, by including age- and sex-matched healthy controls and age-matched hypercholesterolemic controls. Metabolic control and dietary information biochemical markers were obtained from patients with GSDIa. Patients with GSDIa showed higher total serum lysophosphatidylcholine (Fold Change, (FC) 2.2, P < 0.0001), acyl-acylphosphatidylcholine (FC 2.1, P < 0.0001), and ceramide (FC 2.4, P < 0.0001) levels and bile acid (FC 0.7, P < 0.001), acylcarnitines (FC 0.7, P < 0.001), and cholesterol esters (FC 1.0, P < 0.001) than those of healthy controls, and higher di(FC 1.1, P < 0.0001; FC 0.9, P < 0.01) and triacylglycerol (FC 6.3, P < 0.0001; FC 3.9, P < 0.01) levels than those of healthy controls and hypercholesterolemic subjects. Both total cholesterol and triglyceride values correlated with Cer (d16:1/ 22:0), Cer (d18:1/20:0), Cer (d18:1/20:0(OH)), Cer (d18:1/ 22:0), Cer (d18:1/23:0), Cer (d18:1/24:1), Cer (d18:2/22:0), Cer (d18:2/24:1). Total cholesterol also correlated with Cer (d18:1/24:0), Cer (d18:2/20:0), HexCer (d16:1/22:0), HexCer (d18:1/18:0), and Hex2Cer (d18:1/20:0). Triglyceridelevels correlated with Cer (d18:0/24:1). Alanine aminotransferase values correlated with Cer (d18:0/ 22:0), insulin with Cer (d18:1/22:1) and Cer (d18:1/24:1), and HDL with hexosylceramide (HexCer) (d18:2/23:0). These results expand on the currently known involvement of lipid metabolism in GSDIa. Circulating Cer may allow for refined dietary assessment compared with traditional biomarkers. Because specific lipid species are relatively easy to assess, they represent potential novel biomarkers of GSDIa.
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页数:15
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