Camrelizumab-based therapies for the treatment of advanced lung cancer: a prospective, open-label, multicenter, observational, real-world study

被引:0
作者
Zhao, Dong [1 ]
Bi, Minghong [2 ]
Cheng, Xiaofei [3 ]
Wang, Shuhong [4 ]
Cheng, Huaidong [5 ]
Xia, Xiaoyang [6 ]
Chen, Huan [7 ]
Zhang, Yanbei [8 ]
Hu, Zhiqiang [9 ]
Cao, Qisheng [10 ]
Liang, Hui [11 ]
Wang, Fan [12 ]
Min, Xuhong [13 ]
Xu, Ling [14 ]
Feng, Kehai [15 ]
Zhou, Jinhua [16 ]
Li, Xinzhong [17 ]
Wang, Rui [18 ]
Xie, Hua [19 ]
Chen, Xiaosi [20 ]
Gu, Kangsheng [21 ]
机构
[1] Lixin Cty Peoples Hosp, Dept Oncol, Bozhou, Peoples R China
[2] Bengbu Med Coll, Affiliated Hosp 1, Dept Oncol, Bengbu, Peoples R China
[3] Anqing Hosp Navy, Dept Oncol, Anqing, Peoples R China
[4] Huangshan City Peoples Hosp, Dept Oncol, Huangshan, Peoples R China
[5] Anhui Med Univ, Affiliated Hosp 2, Dept Oncol, Hefei, Peoples R China
[6] Chuzhou City First Peoples Hosp, Dept Oncol, Chuzhou, Peoples R China
[7] Anqing Hosp Navy, Dept Pulm & Crit Care Med, Anqing, Peoples R China
[8] Anhui Med Univ, Affiliated Hosp 1, Dept Pulm & Crit Care Med, Hefei, Peoples R China
[9] Huaibei Miner Gen Hosp, Dept Oncol, Huaibei, Peoples R China
[10] Maanshan City Peoples Hosp, Intervent Oncol, Maanshan, Peoples R China
[11] Tradit Chinese Hosp LuAn, Dept Radiol, Luan, Peoples R China
[12] Anhui Med Univ, Affiliated Hosp 1, Dept Radiol, Hefei, Peoples R China
[13] Anhui Chest Hosp, Dept Radiol, Hefei, Peoples R China
[14] Anhui Chest Hosp, Dept Pulm & Crit Care Med, Hefei, Peoples R China
[15] USTC West Dist, Affiliated Hosp 1, Dept Oncol, Hefei, Peoples R China
[16] Anhui Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Oncol, Hefei, Peoples R China
[17] Huaibei City Peoples Hosp, Dept Oncol, Huaibei, Peoples R China
[18] Anhui Chest Hosp, Dept Oncol, Hefei, Peoples R China
[19] Xuancheng City Peoples Hosp, Dept Oncol, Xuancheng, Peoples R China
[20] Dangtu Cty Peoples Hosp, Dept Oncol, Maanshan, Peoples R China
[21] Anhui Med Univ, Affiliated Hosp 1, Dept Oncol, Hefei, Peoples R China
关键词
advanced lung cancer; camrelizumab-based therapies; treatment response; survival; adverse events; 1ST-LINE TREATMENT; PLUS CARBOPLATIN; ADVERSE EVENTS; PHASE-3; CHEMOTHERAPY; PACLITAXEL; CARCINOMA; NIVOLUMAB; EFFICACY; PLACEBO;
D O I
10.3389/fimmu.2025.1494708
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objective: Camrelizumab, a programmed death-1 inhibitor, is effective and safe for treating patients with advanced lung cancer according to previous phase 3 trials. However, relevant real-world clinical evidence is required. This study intended to explore the efficacy and safety of camrelizumab-based therapies in patients with advanced lung cancer. Methods: Patients with advanced lung cancer who received camrelizumab-based therapies as first-line or above treatment were consecutively enrolled in this study. The median follow-up duration was 5 months. Results: A total of 298 subjects were enrolled. Objective response rate (ORR) and disease control rate (DCR) were 27.2% and 82.2%. Multivariable logistic regression analysis showed that previous pulmonary surgery [odds ratio (OR)=0.440, P=0.024], previous radiotherapy (OR=0.410, P=0.010), and Eastern Cooperative Oncology Group Performance Status (ECOG PS) score (>1 vs. 0 similar to 1) (OR=0.414, P=0.046) were independently and negatively associated with ORR. The median progression-free survival (PFS) [95% confidence interval] was 10.0 (7.8-12.2) months. Median overall survival (OS) was not reached. Multivariable Cox regression analysis suggested that brain metastasis [hazard ratio (HR)=1.548, P=0.036] and liver metastasis (HR=1.733, P=0.035) were independently associated with shorter PFS. Previous chemotherapy (HR=2.376, P=0.022), brain metastasis (HR=2.688, P=0.006), and liver metastasis (HR=2.583, P=0.039) were independently associated with shorter OS. Most adverse events were grade I or II. Grade III and IV adverse events rarely occurred. The occurrence of adverse events was associated with a higher DCR (P=0.003). Conclusions: Camrelizumab-based therapies may serve as potential treatments for patients with advanced lung cancer. However, further studies with an extended follow-up duration are warranted.
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页数:13
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