Healthcare-associated infections in patients with COVID-19: is it different from the pre-pandemic period?

被引：0
作者：
Solmaz, Ihsan [1 ]
Kavak, Seyhmus [2 ]
Arac, Songul [3 ]
Akelma, Hakan [4 ]
Basgoz, Bilgin Bahadir [1 ]
Koyun, Sedrettin [5 ]
Kaya, Safak [6 ]
机构：
[1] Univ Hlth Sci, Gazi Yasargil Training & Res Hosp, Dept Internal Med, Elazig Rd 10th Km 1, TR-21070 Diyarbakir, Turkiye
[2] Univ Hlth Sci, Gazi Yasargil Training & Res Hosp, Dept Radiol, Diyarbakir, Turkiye
[3] Univ Hlth Sci, Gazi Yasargil Training & Res Hosp, Dept Emergency, Diyarbakir, Turkiye
[4] Univ Artuklu, Mardin Training & Res Hosp, Dept Anesthesia & Reanimat, Mardin, Turkiye
[5] Kiziltepe State Hosp, Dept Internal Med, Mardin, Turkiye
[6] Univ Hlth Sci, Gazi Yasargil Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkiye
来源：
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES | 2024年 / 18卷 / 09期
关键词：
Healthcare-associated infections; intensive care units; COVID-19;
D O I：
10.3855/jidc.19548
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Introduction: Healthcare-associated infections (HAIs) are common in intensive care unit (ICU) patients and may cause devastating consequences. However, the prevalence of HAI and its effects on in-hospital mortality among critically ill COVID-19 patients is ambiguous. We determined the prevalence of HAI and the rate of mortality in critically ill COVID-19 patients and compared it with pre-pandemic ICU patients. Methodology: This retrospective study was conducted with adult ICU patients admitted to Gazi Ya & scedil;argil Training and Research Hospital (Diyarbakir,Turkey) in April-November 2019 (defined as the pre-pandemic period) and in April-November 2020 (defined as the pandemic period). All patients in the pandemic period had COVID-19, while none in the pre-pandemic period did. Patients diagnosed with HAIs during the in-hospital follow-up period were recorded. Results: Of 4596 enrollees, 3386 (73.7%) were pandemic-period patients and 1210 (26.3%) were pre-pandemic-period patients. HAI prevalence was significantly higher at 5.9% (n = 71) in the pandemic-period patients and 2.7% (n = 91) in the pre-pandemic-period patients (p < 0.001). Comorbidities including hypertension (63.4% vs 14.2%, p < 0.001), diabetes mellitus (39.4% vs 8.8%, p < 0.001), and coronary artery disease (30.9% vs 10.9%, p = 0.002) were significantly more frequent in pandemic-period HAI-positive patients. The most common HAI was catheter- related bloodstream infection in both groups, with similar frequency (p = 0.652). In-hospital mortality rate was 85.9% versus 65.9% in pandemic- versus pre-pandemic-period HAI-positive patients (p < 0,05). Conclusions: The prevalence of HAI and the in-hospital mortality rate was significantly higher among pandemic-period patients.
引用
收藏
页码：S67 / S72
页数：6
相关论文
共 20 条
  • [1] Spencer RC, Epidemiology of infection in ICUs, Intensive Care Med, 20, pp. 2-6, (1994)
  • [2] Guner R, Hasanoglu I, Kayaaslan B, Aypak A, Kaya Kalem A, Eser F, Ozdemir B, Saricaoglu EM, Ayhan M, Aybar Bilir Y, Ozkocak Turan I, Erdem D, Mutlu NM, Buzgan T, Dinc B, Akinci E, COVID-19 experience of the major pandemic response center in the capital: results of the pandemic's first month in Turkey, Turk J Med Sci, 50, pp. 1801-1809, (2020)
  • [3] Medetalibeyoglu A, Senkal N, Kose M, Catma Y, Bilge Caparali E, Erelel M, Oral Oncul M, Bahat G, Tukek T, Older Adults Hospitalized with Covid-19: Clinical Characteristics and Early Outcomes from a Single Center in Istanbul, Turkey, J Nutr Health Aging, 24, pp. 928-937, (2020)
  • [4] Fakhreddine S, Fawaz M, Hassanein S, Al Khatib A, Prevalence and mortality rate of healthcare-associated infections among COVID-19 patients: a retrospective cohort community-based approach, Front Public Health, 11, (2023)
  • [5] Bardi T, Pintado V, Gomez-Rojo M, Escudero-Sanchez R, Azzam Lopez A, Diez-Remesal Y, Martinez Castro N, Ruiz-Garbajosa P, Pestana D, Nosocomial infections associated to COVID-19 in the intensive care unit: clinical characteristics and outcome, Eur J Clin Microbiol Infect Dis, 40, pp. 495-502, (2021)
  • [6] O'Toole RF, The interface between COVID-19 and bacterial healthcare-associated infections, Clin Microbiol Infect, 27, pp. 1772-1776, (2021)
  • [7] Grasselli G, Scaravilli V, Mangioni D, Scudeller L, Alagna L, Bartoletti M, Bellani G, Biagioni E, Bonfanti P, Bottino N, Coloretti I, Cutuli SL, De Pascale G, Ferlicca D, Fior G, Forastieri A, Franzetti M, Greco M, Guzzardella A, Linguadoca S, Meschiari M, Messina A, Monti G, Morelli P, Muscatello A, Redaelli S, Stefanini F, Tonetti T, Antonelli M, Cecconi M, Foti G, Fumagalli R, Girardis M, Ranieri M, Viale P, Raviglione M, Pesenti A, Gori A, Bandera A, Hospital-Acquired Infections in Critica
  • [8] Kwon JH, Nickel KB, Reske KA, Stwalley D, Dubberke ER, Lyons PG, Michelson A, McMullen K, Sahrmann JM, Gandra S, Olsen MA, Burnham JP, Risk factors for hospital-acquired infection during the SARS-CoV-2 pandemic, J Hosp Infect, 133, pp. 8-14, (2023)
  • [9] Turkey announces its first case of coronavirus, (2020)
  • [10] Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM, CDC definitions for nosocomial infections, 1988, Am J Infect Control, 16, pp. 128-140, (1988)
12