How to facilitate the dissemination of pharmacogenetic tests?

被引:0
作者
Verstuyft, Celine [1 ]
Dewolf, Dominique [2 ]
Blin, Olivier [3 ]
Florentin, Virginie [4 ]
Mesnard, Laurent [5 ]
Chaumette, Boris [6 ]
Ayme-Dietrich, Estelle [7 ]
Raymond, Laure [8 ]
Lang, Marie [9 ]
Lamaziere, Antonin [10 ]
Allard, Beatrice [11 ]
Samelson, Laurence [12 ]
Lamezec, Liliane [13 ]
Loriot, Marie-Anne [14 ]
Le Bozec, Antoine [15 ]
Picard, Nicolas [16 ]
机构
[1] Univ Paris Saclay, Hop Univ Paris Saclay,Fac Medecine, Hop Bicetre,Serv Genet Mol Pharmacogenet & Hormon, AP HP,CESP,Inserm UMR 1018,MOODS Team, F-94275 Le Kremlin Bicetre, France
[2] ThermoFisher Sci, F-91941 Villebon Sur Yvette, France
[3] Aix Marseille Univ, AP HM, Serv Pharmacol Clin & Pharmacosurveillance, UMR Inserm 1106, F-13000 Marseille, France
[4] Roche SAS, Direct Med Personnalisee, F-92600 Boulogne Billancourt, France
[5] Hop Univ Paris Saclay, Hop Tenon, AP HP, Serv Nephrol,Inserm UMR1155, F-75020 Paris, France
[6] Univ Paris Cite, Hop Ste Anne, GHU Paris Psychiat & Neurosci, Inserm U1266,GHU Paris Psychiat & Neurosci, Paris, France
[7] Univ Strasbourg, UR7296, Lab Pharmacol & Toxicol Neurocardiovasc, Strasbourg, France
[8] Eurofins Biomnis, Lab Genet, Lyon, France
[9] INSERM, F-75014 Paris, France
[10] Sorbonne Univ, St Antoine Hop, AP HP,Ctr Rech St Antoine, Dept Metabol Clin, F-75012 Paris, France
[11] Amgen Inc, Dept Affaires Med, F-92400 Courbevoie, France
[12] INSERM, Direct Med, F-69003 Lyon, France
[13] Bristol Myers Squibb, F-92500 Rueil Malmaison, France
[14] Univ Paris Cite, Georges Pompidou European Hosp, AP HP,Ctr Rech Cordeliers, Dept Clin Chem,Inserm UMRS1138, Paris, France
[15] Hop Bicetre, AP HP, Serv Pharm, F-94270 Le Kremlin Bicetre, France
[16] CHU Limoges, Ctr Biol & Rech Sante Pharmacol Toxicol & Pharmac, F-87042 Limoges, France
来源
THERAPIE | 2025年 / 80卷 / 01期
关键词
Genomics; Iatrogenesis; Artificial intelligence; Personalized medicine; Pharmacogenetics;
D O I
10.1016/j.therap.2024.11.007
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The 4 Ps of medicine (personalized, preventive, predictive, participatory) are experiencing a remarkable boom, and pharmacogenetics is an essential part of it. However, a number of obstacles stand in the way of its deployment. This round table brought together a group of experts to take stock of the current situation, and to consider ways of facilitating the prescription of these tests and the dissemination of results on a national scale. The experts looked at ways of prescribing and communicating pharmacogenetic data in the current context, but also in the coming years with the arrival of artificial intelligence software. Questions relating to the reimbursement of tests were also discussed, as this is a key factor in ensuring that all patients have access to these tests. Numerous recommendations were made on these various points, aimed at making it easier for healthcare professionals to control prescribing, while guaranteeing that results can be stored and used throughout the patient's life. Finally, it was recommended that patients should be better informed, and that healthcare professionals and manufacturers should be more closely involved in the process, emphasizing the training and commitment required to ensure its success.
引用
收藏
页码:93 / 102
页数:10
相关论文
共 15 条
  • [1] [Anonymous], 2013, Legifrance. Arrete du 27 mai 2013 definissant les regles de bonnes pratiques applicables a l'examen des caracte- ristiques genetiques d'une personne a des fins medicales
  • [2] [Anonymous], 2008, Legifrance. Decret no 2008-321 du 4 avril 2008 relatif a l'examen des caracteristiques genetiques d'une personne ou a son identification par empreintes genetiques a des fins medicales, P2008
  • [3] ANSM, 2023, Actualite-chimiotherapies a base de 5-FU ou capecitabine: la recherche d'un deficit en DPD (dihydropyrimidine deshydrogenase) est obligatoire avant tout debut de traitement
  • [4] Council for International Organizations of Medical Sciences, 2005, Pharmacogenetics: towards improving treatment with medicines
  • [5] Food and Drug Administration HHS, 2008, Fed Regist, V73, P19074
  • [6] Haute autorite de sante, 2023, Methodes de recherche d'un deficit en dihydropyrimidine deshydrogenase visant a prevenir certaines toxicites severes associees aux traitements incluant une fluoropyrimidine (5-fluorouracile ou capecitabine)
  • [7] Lack of guidelines and translational knowledge is hindering the implementation of psychiatric genetic counseling and testing within Europe-A multi-professional survey study
    Koido, Kati
    Malmgren, Charlotta Ingvoldstad
    Pojskic, Lejla
    Almos, Peter Z.
    Bergen, Sarah E.
    Borg, Isabella
    Bozina, Nada
    Coviello, Domenico A.
    Degenhardt, Franziska
    Ganoci, Lana
    Jensen, Uffe B.
    Durand-Lennad, Louise
    Laurent-Levinson, Claudine
    McQuillin, Andrew
    Navickas, Alvydas
    Pace, Nikolai P.
    Paneque, Milena
    Rietschel, Marcella
    Grigoroiu-Serbanescu, Maria
    Soller, Maria Johansson
    Suvisaari, Jaana
    Utkus, Algirdas
    Van Assche, Evelien
    Vissouze, Lily
    Zuckerman, Shachar
    Chaumette, Boris
    Tammimies, Kristiina
    [J]. EUROPEAN JOURNAL OF MEDICAL GENETICS, 2023, 66 (08)
  • [8] Acceptability of Pharmacogenetic Testing among French Psychiatrists, a National Survey
    Laplace, Benjamin
    Calvet, Benjamin
    Lacroix, Aurelie
    Mouchabac, Stephane
    Picard, Nicolas
    Girard, Murielle
    Charles, Eric
    [J]. JOURNAL OF PERSONALIZED MEDICINE, 2021, 11 (06):
  • [9] Economic burden of hospital admissions for adverse drug reactions in France: The IATROSTAT-ECO study
    Laroche, Marie-Laure
    Tarbouriech, Noemie
    Jai, Taha
    Valnet-Rabier, Marie-Blanche
    Nerich, Virginie
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2024, : 439 - 450
  • [10] Incidence and preventability of hospital admissions for adverse drug reactions in France: A prospective observational study (IATROSTAT)
    Laroche, Marie-Laure
    Gautier, Sophie
    Polard, Elisabeth
    Rabier, Marie-Blanche
    Chouchana, Laurent
    Lebrun-Vignes, Benedicte
    Faillie, Jean-Luc
    Petitpain, Nadine
    Lagarce, Laurence
    Jonville-Bera, Annie-Pierre
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2023, 89 (01) : 390 - 400