Anesthesia effects of different doses of fospropofol disodium for painless colonoscopy diagnosis and treatment

Purpose: To explore the clinical anesthesia effect of different doses of fospropofol disodium for painless colonoscopy. Patients and methods: A total of 69 patients undergoing colonoscopy under general intravenous anesthesia were included in this study. They were divided into three groups: fospropofol disodium 10 mg/kg group (P1 group, n = 23), fospropofol disodium 12.5 mg/kg group (P2 group, n = 23), and fospropofol disodium 15 mg/kg group (P3 group, n = 23). All patients were first injected with 5 mu g/kg of alfentanil intravenously at the time of anesthesia induction, 1 min later, group P1, group P2 and group P3 were given 10 mg/kg, 12.5 mg/kg and 15 mg/kg of fospropofol disodium, respectively. The success rate of the first sedation, the time of sedation start, the time of awakening, hemodynamic changes and adverse reactions were recorded. Results: The success rate of first sedation in the P2 and P3 groups was significantly higher than that in the P1 group (p < 0.05). The onset time of sedation was significantly shorter in the P2 and P3 groups than in the P1 group (p < 0.05). The awakening time of the P2 group and the P3 group (9 min vs. 7 min) was significantly longer than that of the P1 group (5 min) (p < 0.05). The incidence of hypotension in the P3 group was significantly higher than that in the P1 and P2 groups (p < 0.05). At T2, the MAP of the P3 group decreased significantly compared with the P1 and P2 groups (p < 0.05). There were no significant differences in adverse reactions such as injection pain, abnormal sensation/itching between the three groups (p > 0.05). Conclusion: In painless colonoscopy, fospropofol disodium 12.5 mg/kg combined with alfentanil 5 mu g/kg has a high success rate of first-time sedation and low hemodynamic impact, which has some clinical advantages. Clinical trial registration: ChiCTR2400090788.