Utilization of nanotechnology to surmount the blood-brain barrier in disorders of the central nervous system

被引：6

作者：

Luo, Qian ^{[1
,2
,3
]}

Yang, Jiaying ^{[2
,3
]}

Yang, Mei ^{[2
,3
]}

Wang, Yingtong ^{[4
]}

Liu, Yiran ^{[1
]}

Liu, Jixuan ^{[2
,3
]}

Kalvakolanu, Dhan, V ^{[5
]}

Cong, Xianling ^{[1
]}

Zhang, Jinnan ^{[1
]}

Zhang, Ling ^{[2
,3
]}

Guo, Baofeng ^{[1
]}

Duo, Yanhong ^{[6
]}

机构：

[1] Jilin Univ, China Japan Union Hosp, Dept Plast Surg, Changchun 130033, Peoples R China

[2] Jilin Univ, Coll Basic Med Sci, Key Lab Pathobiol, Minist Educ, Changchun 130021, Peoples R China

[3] Jilin Univ, Coll Basic Med Sci, Dept Biomed Sci, Changchun 130021, Peoples R China

[4] Jilin Univ, Hosp Stomatol, Undergraduate Ctr, Changchun 130021, Peoples R China

[5] Univ Maryland, Greenebaum NCI Comprehens Canc Ctr, Sch Med, Dept Microbiol & Immunol, Baltimore, MD USA

[6] Harvard Univ, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA

来源：

MATERIALS TODAY BIO | 2025年 / 31卷

基金：

中国国家自然科学基金;

关键词：

Nanoscale delivery platforms; Nano-sized particles; Disorders of the central nervous system; Cerebrovascular barrier; ENHANCED DRUG-DELIVERY; SILICA NANOPARTICLES; PARKINSONS-DISEASE; IN-VITRO; GOLD NANOPARTICLES; LOADED LIPOSOMES; TUMOR BARRIER; GENE DELIVERY; GLIOBLASTOMA; THERAPY;

D O I：

10.1016/j.mtbio.2025.101457

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Central nervous system (CNS) diseases are a major cause of disability and death worldwide. Due to the bloodbrain barrier (BBB), drug delivery for CNS diseases is extremely challenging. Nano-delivery systems can overcome the limitations of BBB to deliver drugs to the CNS, improve the ability of drugs to target the brain and provide potential therapeutic methods for CNS diseases. At the same time, the choice of different drug delivery methods (bypassing BBB or crossing BBB) can further optimize the therapeutic effect of the nano-drug delivery system. This article reviews the different methods of nano-delivery systems to overcome the way BBB enters the brain. Different kinds of nanoparticles to overcome BBB were discussed in depth.

引用

页数：32

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