Evaluating the Cartilage Oligomeric Matrix Protein Levels in Sera of Iraqi Patients with Rheumatoid Arthritis

The biomarker significance of chemokine (Cartilage Oligomeric Matrix Protein) was evaluated in the sera of 80 rheumatoid arthritis (RA) patients and 40 control men and women. A test ELISA kit was used in the Human Reader HS apparatus to measure the serum COMP, CRP, and RF. The Nihon Kohden Europes (MEK-6550K) analyzer apparatus was used for the testing of Complete Blood Count and the erythrocyte sedimentation rate (ESR), The Westergren device was used in this evaluation. The results demonstrated that COMP, CRP, RF, and ESR showed a significantly increased median in RA patients compared to control (COMP:104.79 f 1.95 vs. 47.79 f 1.34 ng/ml; CRP: 2442.09 f 172.32 vs. 1271.41 f 35.14 pg/ml; RF: 0.92 f 0.03 vs. 0.34 f 0.024 ng/ml; ESR: 33.81 f 2.52 vs. 15.53 f 1.13 MM/H). Binary logistic regression analysis revealed that COMP was a significant predictor of RA. The ROC curve analysis also revealed that COMP recorded an area under the curve of 1.00 in RA patients. In conclusion, serum COMP is a reliable diagnostic parameter that may accurately distinguish between those with active RA and control individuals.