TRPS1 Expression Is Frequently Seen in a Subset of Cutaneous Mesenchymal Neoplasms and Tumors of Uncertain Differentiation: A Potential Diagnostic Pitfall

被引:2
作者
Kim, Moon Joo [1 ]
Liu, Yi A. [2 ]
Wang, Yunyi [3 ]
Ning, Jing [3 ]
Cho, Woo Cheal [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr Houston, Dept Anat Pathol, Houston, TX 77030 USA
[2] Royal Columbian Hosp, Dept Pharm, Dept Pathol & Lab Med, New Westminster, BC V3L 3W7, Canada
[3] Univ Texas MD Anderson Canc Ctr Houston, Dept Biostat, Houston, TX 77030 USA
来源
DERMATOPATHOLOGY | 2024年 / 11卷 / 03期
关键词
TRPS1; immunohistochemistry; cutaneous mesenchymal neoplasms; cutaneous tumors of uncertain differentiation; atypical fibroxanthoma;
D O I
10.3390/dermatopathology11030021
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Although extensively studied in cutaneous epithelial neoplasms, the TRPS1 immunoreactivity in cutaneous mesenchymal neoplasms and tumors of uncertain differentiation (CMNTUDs), such as atypical fibroxanthoma (AFX), remains largely unexplored. We assessed TRPS1 immunoreactivity in 135 CMNTUDs, comprising 46 fibrohistiocytic/fibroblastic tumors, 28 vascular tumors, 24 peripheral nerve sheath tumors (PNSTs), 21 tumors of uncertain differentiation, and 16 smooth muscle tumors. Additionally, we included selected cases of melanoma with spindled cell morphology or desmoplastic features (n = 9) and sarcomatoid squamous cell carcinoma (SSCC) (n = 5) to compare TRPS1 expression patterns with those of AFX. TRPS1 expression was prevalent in dermatofibromas (24/24), leiomyomas (8/8), AFXs/pleomorphic dermal sarcoma (PDS) (20/21), dermatofibrosarcomas protuberans (14/22), and leiomyosarcomas (6/8). It was uncommon in angiosarcomas (3/20), Kaposi sarcomas (2/8), and neurofibromas (5/17) and absent in perineuriomas (0/2). AFXs/PDS exhibited the highest median H-score of 240, contrasting with minimal TRPS1 immunoreactivity in vascular neoplasms and PNSTs, with median H-scores consistently below 10. Significant differences in H-score were observed between AFXs/PDS and angiosarcomas (p < 0.001), melanomas (p < 0.001), and leiomyosarcomas (p = 0.029). However, no significant difference was found compared to SSCCs, suggesting limited discriminatory power of TRPS1 in this context. This study sheds light on TRPS1 expression patterns in a subset of CMNTUDs, extending beyond prior studies primarily focused on epithelial tumors, while underscoring potential pitfalls associated with TRPS1 immunohistochemistry.
引用
收藏
页码:200 / 208
页数:9
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