Green Synthesis of Zinc Oxide Nanoparticles Using Puerarin: Characterization, Antimicrobial Potential, Angiogenesis, and In Ovo Safety Profile Assessment

被引:0
作者
Liga, Sergio [1 ]
Voda, Raluca [2 ]
Lupa, Lavinia [2 ]
Paul, Cristina [1 ]
Nemes, Nicoleta Sorina [3 ]
Muntean, Delia [4 ]
Avram, Stefana [5 ]
Gherban, Mihaela [6 ]
Peter, Francisc [1 ,3 ]
机构
[1] Politehn Univ Timisoara, Fac Chem Engn Biotechnol & Environm Protect, Dept Appl Chem & Engn Organ & Nat Cpds, Vasile Parvan 6, Timisoara 300223, Romania
[2] Politehn Univ Timisoara, Fac Chem Engn Biotechnol & Environm Protect, Dept Appl Chem & Environm Engn & Inorgan Cpds, Vasile Parvan 6, Timisoara 300223, Romania
[3] Politehn Univ Timisoara, Renewable Energy Res Inst ICER, Gavril Musicescu St 138, Timisoara 300501, Romania
[4] Victor Babes Univ Med, Fac Med, Multidisciplinary Res Ctr Antimicrobial Resistance, Dept Microbiol, 2nd Eftimie Murgu Sq, Timisoara 300041, Romania
[5] Victor Babes Univ Med & Pharm, Fac Pharm, Dept Pharmacognosy, Eftimie Murgu Sq 2, Timisoara 300041, Romania
[6] Natl Inst Res & Dev Electrochem & Condensed Matter, P Andronescu St 1, Timisoara 300224, Romania
关键词
puerarin; zinc oxide nanoparticles; metallic nanoparticles; green synthesis; CAM assay; CHORIOALLANTOIC MEMBRANE; ZNO NANOPARTICLES; ANTIOXIDANT; EXTRACTS; CATALYST; AGENTS;
D O I
10.3390/pharmaceutics16111464
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: Zinc oxide nanobiocomposites were successfully synthesized using a green synthesis approach. The process involves the utilization of the isoflavone puerarin, resulting in the formation of PUE-ZnO NPs. Methods: Physico-chemical and biological characterization techniques including X-ray dif-fraction (XRD), UV-vis spectroscopy, Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), and in ovo methods were employed to study the main characteristics of this novel hybrid material. Results: The PUE-ZnO NPs were confirmed to have been successfully synthesized with a UV absorption peak at 340 nm, the XRD analysis demonstrating their high purity and crystallinity. The energy band-gap value of 3.30 eV suggests possible photocatalytic properties. Both SEM and AFM images revealed the nanoparticle`s quasi-spherical shape, roughness, and size. Good tolerability and anti-irritative effects were recorded in ovo on the chorioallantoic membrane (CAM). Conclusions: According to these results, the synthesis of green PUE-ZnO NPs may be a promising future approach for biomedical and personal care applications.
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页数:16
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