Understanding the Impact of the Sirtuin 1 (SIRT1) Gene on Age-related Macular Degeneration: A Comprehensive Study

被引:0
|
作者
Velmurugan, Saranya [1 ]
Pauline, Rashmi [1 ]
Chandrashekar, Gurudeva [2 ]
Kulanthaivel, Langeswaran [3 ]
Subbaraj, Gowtham Kumar [1 ]
机构
[1] Chettinad Acad Res & Educ, Chettinad Hosp & Res Inst, Fac Allied Hlth Sci, Med Genet Div, Kelambakkam 603103, Tamil Nadu, India
[2] Karuna Med Coll, Dept Pharmacol, Palakkad, Kerala, India
[3] Alagappa Univ, Dept Biomed Sci, Sci Campus, Karaikkudi, Tamil Nadu, India
关键词
Age-related macular degeneration; age-related macular degeneration risk; biomarker; genetic variants; SIRT1; OCULAR BLOOD-FLOW; OXIDATIVE STRESS; HUMAN RPE; EPIDEMIOLOGY; CELLS; RISK; PATHOGENESIS; ACTIVATION; APOPTOSIS; BURDEN;
D O I
10.4103/npmj.npmj_9_24
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Age-related macular degeneration (AMD) is a prevalent and incurable condition affecting the central retina and posing a significant risk to vision, particularly in individuals over the age of 60. As the global population ages, the prevalence of AMD is expected to rise, leading to substantial socioeconomic impacts and increased healthcare costs. The disease manifests primarily in two forms, neovascular and non-neovascular, with genetic, environmental and lifestyle factors playing a pivotal role in disease susceptibility and progression. This review article involved conducting an extensive search across various databases, including Google Scholar, PubMed, Web of Science, ScienceDirect, Scopus and EMBASE, to compile relevant case-control studies and literature reviews from online published articles extracted using search terms related to the work. SIRT1, a key member of the sirtuin family, influences cellular processes such as ageing, metabolism, DNA repair and stress response. Its dysregulation is linked to retinal ageing and ocular conditions like AMD. This review discusses the role of SIRT1 in AMD pathology, its association with genetic variants and its potential as a biomarker, paving the way for targeted interventions and personalised treatment strategies. In addition, it highlights the findings of case-control studies investigating the relationship between SIRT1 gene polymorphisms and AMD risk. These studies collectively revealed a significant association between certain SIRT1 gene variants and AMD risk. Further studies with larger sample sizes are required to validate these findings. As the prevalence of AMD grows, understanding the role of SIRT1 and other biomarkers becomes increasingly vital for improving diagnosis, treatment and, ultimately, patient outcomes.
引用
收藏
页码:93 / 101
页数:9
相关论文
共 50 条
  • [31] Differential Gene Expression in Age-Related Macular Degeneration
    Morgan, Denise J.
    DeAngelis, Margaret M.
    COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2015, 5 (08): : 1 - 11
  • [32] How genetic studies have advanced our understanding of age-related macular degeneration and their impact on patient care: a review
    Baird, Paul N.
    Chakrabarti, Subhabrata
    CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2014, 42 (01): : 53 - 64
  • [33] Plasma Lutein, a Nutritional Biomarker for Development of Advanced Age-Related Macular Degeneration: The Alienor Study
    Merle, Benedicte M. J.
    Cougnard-Gregoire, Audrey
    Korobelnik, Jean-Francois
    Schalch, Wolfgang
    Etheve, Stephane
    Rougier, Marie-Benedicte
    Feart, Catherine
    Samieri, Cecilia
    Delyfer, Marie-Noelle
    Delcourt, Cecile
    NUTRIENTS, 2021, 13 (06)
  • [34] Gene therapy for age-related macular degeneration: potential, feasibility, and pitfalls
    Berkowitz, Sean T.
    Finn, Avni P.
    CURRENT OPINION IN OPHTHALMOLOGY, 2024, 35 (03) : 170 - 177
  • [35] Age-Related Macular Degeneration and the Risk of Stroke The Rotterdam Study
    Wieberdink, Renske G.
    Ho, Lintje
    Ikram, M. Kamran
    Koudstaal, Peter J.
    Hofman, Albert
    de Jong, Paulus T. V. M.
    Vingerling, Johannes R.
    Breteler, Monique M. B.
    STROKE, 2011, 42 (08) : 2138 - 2142
  • [36] An association of transferrin gene polymorphism and serum transferrin levels with age-related macular degeneration
    Wysokinski, Daniel
    Danisz, Katarzyna
    Blasiak, Janusz
    Dorecka, Mariola
    Romaniuk, Dorota
    Szaflik, Jerzy
    Szaflik, Jacek Pawel
    EXPERIMENTAL EYE RESEARCH, 2013, 106 : 14 - 23
  • [37] HMGB1 and Caveolin-1 related to RPE cell senescence in age-related macular degeneration
    Sun, Shuo
    Cai, Bincui
    Li, Yao
    Su, Wenqi
    Zhao, Xuzheng
    Gong, Boteng
    Li, Zhiqing
    Zhang, Xiaomin
    Wu, Yalin
    Chen, Chao
    Tsang, Stephen H.
    Yang, Jin
    Li, Xiaorong
    AGING-US, 2019, 11 (13): : 4323 - 4337
  • [38] B Vitamins and Incidence of Advanced Age-Related Macular Degeneration: The Alienor Study
    Merle, Benedicte M. J.
    Barthes, Stephanie
    Feart, Catherine
    Cougnard-Gregoire, Audrey
    Korobelnik, Jean-Francois
    Rougier, Marie-Benedicte
    Delyfer, Marie-Noelle
    Delcourt, Cecile
    NUTRIENTS, 2022, 14 (14)
  • [39] ALTERED SERUM LEVELS OF AUTOPHAGY PROTEINS BECLIN-1 AND mTOR IN PATIENTS WITH EXUDATIVE AGE-RELATED MACULAR DEGENERATION
    Kubicka-Trzaska, A.
    Zuber-Laskawiec, K.
    Plutecka, H.
    Romanowska-Dixon, B.
    Sanak, M.
    Karska-Basta, I.
    JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021, 72 (01):
  • [40] TSP1 ameliorates age-related macular degeneration by regulating the STAT3-iNOS signaling pathway
    Li, Jing
    He, Jiaqi
    Zhang, Xiang
    Li, Jiakai
    Zhao, Peiquan
    Fei, Ping
    EXPERIMENTAL CELL RESEARCH, 2020, 388 (01)