Advances in Encapsulating Marine Bioactive Compounds Using Nanostructured Lipid Carriers (NLCs) and Solid Lipid Nanoparticles (SLNs) for Health Applications

被引:4
作者
Favas, Rita [1 ,2 ]
Almeida, Hugo [1 ,2 ,3 ]
Peixoto, Andreia F. [4 ]
Ferreira, Domingos [1 ,2 ]
Silva, Ana C. [1 ,2 ,5 ]
机构
[1] Univ Porto, Fac Pharm, UCIBIO Appl Mol Biosci Unit, Lab Pharmaceut Technol, P-4050313 Porto, Portugal
[2] Univ Porto, Inst Hlth & Bioecon i4HB, Fac Pharm, Associate Lab, P-4050313 Porto, Portugal
[3] Mesosyst Invest & Investimentos Spinpark, P-4805017 Guimaraes, Portugal
[4] Univ Porto, Fac Ciencias, Dept Quim & Bioquim, LAQV REQUIMTE Associated Lab Green Chem Network Ch, P-4169007 Porto, Portugal
[5] Univ Fernando Pessoa, Fac Hlth Sci, FP I3ID Inst Invest Inovacao & Desenvolvimento, FP BHS Biomed & Hlth Sci Res Unit, P-4249004 Porto, Portugal
关键词
healthcare; cosmetics; food supplements; marine bioactive compounds; lipid nanoparticles; IN-VITRO; VITAMIN-E; FORMULATIONS; DELIVERY; BIOCOMPATIBILITY;
D O I
10.3390/pharmaceutics16121517
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
As life expectancy rises and modern lifestyles improve, there is an increasing focus on health, disease prevention, and enhancing physical appearance. Consumers are more aware of the benefits of natural ingredients in healthcare products while also being mindful of sustainability challenges. Consequently, marine bioactive compounds have gained popularity as ingredients in cosmetics and food supplements due to their diverse beneficial properties. Nonetheless, the use of some of these compounds is restricted by their low stability and poor aqueous solubility, necessitating solutions to overcome these limitations. In this context, lipid nanoparticles, such as solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), have been investigated for their potential to protect and improve the absorption of molecules through various routes, including oral and cutaneous. Numerous studies have shown that nanoencapsulating these compounds and incorporating them into cosmetics and food supplements can be effective. However, this application remains unregulated at the global level and is not currently addressed by existing legislation. Additional in vivo studies in both animals and humans are necessary to fully assess safety concerns.
引用
收藏
页数:22
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