Neodymium doped nanosheet-assembled hierarchical Co3O4 nanoflowers modified electrode as an electrochemical sensor for the voltammetric determination of linezolid in the presence of theophylline

An electrochemical sensing platform based on a neodymium doped nanosheet-assembled hierarchical Co3O4 nanoflower modified screen-printed electrode (Nd3+/NAH Co3O4 NF/SPE) was employed for electroanalytical sensing of linezolid. Moreover, this study applied differential pulse voltammetry (DPV), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), as well as, chronoamperometry (CA) for characterizing the electrochemical sensor features. As demonstrated by the analyses, the effects of Nd3+/NAH Co3O4 NF caused electro-catalytic-type response, which considerably enhanced the electroanalytical response for linezolid in comparison with an unmodified SPE. Then, the new sensor was employed for detecting linezolid in the presence of theophylline, in which a linear range between 1.0 x 10-9 and 500.0 x 10-6 mol L- 1 with significant correlation and acceptable linearity were obtained with the LODs 0.13 x 10-9 and 0.22 x 10-9 mol L- 1 for linezolid and theophylline, respectively. Considering the findings, this new sensor could be utilized successfully for determining linezolid and theophylline in the real samples with acceptable recovery. Thus, this electrochemical sensing platform is easy and economical with the possible use for quality control, typical detection of medicines, and clinical analyses in the drug formulations.