Site-Selective Synthetic Modifications of the Cinchona Alkaloids

被引：1

作者：

Player, Finlay P. ^{[1
]}

Foley, Daniel J. ^{[1
,2
]}

机构：

[1] Univ Canterbury, Sch Phys & Chem Sci, Christchurch, New Zealand

[2] Univ Canterbury, Biomol Interact Ctr, Christchurch, New Zealand

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 13卷 / 12期

关键词：

Alkaloids; Natural Products; Synthesis design; Reaction mechanisms; CHIRAL STATIONARY PHASES; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC FLUORINATION; GRIGNARD-REAGENTS; MICHAEL ADDITION; ETHYL PYRUVATE; COMBINED NMR; C-C; QUININE; DERIVATIVES;

D O I：

10.1002/ajoc.202400397

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The natural product quinine has been known to humankind for centuries, and in that time has played a pivotal role in the treatment of malaria. Quinine, and the related cinchona alkaloids, have seen widespread contemporary use across chemical and biological disciplines, owing in part to the plethora of functional groups and stereochemical information contained within their scaffold. This review focuses on site-selective synthetic modifications of the cinchona alkaloids. Our comparative analysis may act as a 'user manual' for the selective functionalisation of the cinchona alkaloids, and aims to promote consideration of remarkable and lesser-understood aspects of cinchona chemistry.

引用

页数：26

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