Shadows and lights in sepsis immunotherapy

被引:0
作者
Monneret, Guillaume [1 ,2 ]
Rahimi, Muzhda Haem [1 ,2 ]
Lukaszewicz, Anne-Claire [2 ,3 ]
Venet, Fabienne [1 ,4 ]
Gossez, Morgane [1 ,4 ]
机构
[1] Hosp Civils Lyon, Hop E Herriot, Immunol Lab, Lyon, France
[2] Univ Claude Bernard Lyon 1, Univ Lyon, Pathophysiol Injury Induced Immunosuppress, EA 7426, Lyon, France
[3] Hosp Civils Lyon, Hop E Herriot, Anesthesiol & Crit Care Med Dept, Lyon, France
[4] Univ Lyon, Univ Claude Bernard, Ctr Int Rech Infectiol, CIRI,Inserm,U1111,CNRS,UMR5308,ENS de Lyon, F-69007 Lyon, France
关键词
Sepsis; septic shock; inflammation; mHLA-DR; immunosuppression; immunotherapy; HUMAN-LEUKOCYTE ANTIGEN; CRITICALLY-ILL PATIENTS; HLA-DR EXPRESSION; SEPTIC SHOCK; FRAGMENT AFELIMOMAB; IMMUNOSUPPRESSION; MORTALITY; PATHOPHYSIOLOGY; DYSFUNCTION; PNEUMONIA;
D O I
10.1080/14656566.2024.2418987
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Introduction: Sepsis remains a major global public health challenge. The host's response in sepsis involves both an exaggerated inflammatory reaction and immunosuppressive mechanisms. A better understanding of this response has shed light on the failure of anti-inflammatory therapies administered under the 'one size fits all' approach during the last decades. Areas covered: To date, patients' management has moved toward a comprehensive precision medicine approach that aims to personalize immunotherapy, whether anti-inflammatory or immunostimulatory. Large Prospective interventional randomized controlled trials validating this approach are about to start. A crucial prerequisite for these studies is to stratify patients based on biomarkers that will help defining the patients' immuno-inflammatory trajectory. Expert opinion: Some biomarkers are already available in routine clinical care, while improvements are anticipated through the standardized use of transcriptomics and other multi-omics technologies in this field. With these precautions in mind, it is reasonable to anticipate improvement in outcomes in sepsis.
引用
收藏
页码:2125 / 2133
页数:9
相关论文
共 80 条
  • [61] Towards personalized medicine: a scoping review of immunotherapy in sepsis
    Slim, Marleen A.
    van Mourik, Niels
    Bakkerus, Lieke
    Fuller, Katherine
    Acharya, Lydia
    Giannidis, Tatiana
    Dionne, Joanna C.
    Oczkowski, Simon J. W.
    Netea, Mihai G.
    Pickkers, Peter
    Giamarellos-Bourboulis, Evangelos J.
    Muller, Marcella C. A.
    van der Poll, Tom
    Wiersinga, W. Joost
    Vlaar, Alexander P. J.
    van Vught, Lonneke A.
    [J]. CRITICAL CARE, 2024, 28 (01)
  • [62] Immunomodulators in COVID-19: Two Sides to Every Coin
    Snow, Timothy A. C.
    Singer, Mervyn
    Arulkumaran, Nishkantha
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 202 (10) : 1460 - 1461
  • [63] Prognostic and predictive enrichment in sepsis
    Stanski, Natalja L.
    Wong, Hector R.
    [J]. NATURE REVIEWS NEPHROLOGY, 2020, 16 (01) : 20 - 31
  • [64] Clinical study of rhGM-CSF for the treatment of pulmonary exogenous acute respiratory distress syndrome by modulating alveolar macrophage subtypes: A randomized controlled trial
    Sun, Jie
    Zhang, Xiaokun
    Ma, Liliang
    Yang, Yong
    Li, Xia
    [J]. MEDICINE, 2023, 102 (19) : E33770
  • [65] Macroscopic Postmortem Findings in 235 Surgical Intensive Care Patients with Sepsis
    Torgersen, Christian
    Moser, Patrizia
    Luckner, Guenter
    Mayr, Viktoria
    Jochberger, Stefan
    Hasibeder, Walter R.
    Duenser, Martin W.
    [J]. ANESTHESIA AND ANALGESIA, 2009, 108 (06) : 1841 - 1847
  • [66] Effect of Corticosteroids on Treatmmt Failure Among Hospitalized Patients With Severe Community-Acquired Pneumonia and High Inflammatory Response A Randomized Clinical Trial
    Torres, Antoni
    Sibila, Oriol
    Ferrer, Miguel
    Polverino, Eva
    Menendez, Rosario
    Mensa, Josep
    Gabarrus, Albert
    Sellares, Jacobo
    Restrepo, Marcos I.
    Anzueto, Antonio
    Niederman, Michael S.
    Agusti, Caries
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2015, 313 (07): : 677 - 686
  • [67] Sepsis-Induced Immunosuppression
    Torres, Lisa K.
    Pickkers, Peter
    van der Poll, Tom
    [J]. ANNUAL REVIEW OF PHYSIOLOGY, 2022, 84 : 157 - 181
  • [68] A stratification strategy to predict secondary infection in critical illness-induced immune dysfunction: the REALIST score
    Tremblay, Jan-Alexis
    Peron, Florian
    Kreitmann, Louis
    Textoris, Julien
    Brengel-Pesce, Karen
    Lukaszewicz, Anne-Claire
    Quemeneur, Laurence
    Vedrine, Christophe
    Tan, Lionel K.
    Venet, Fabienne
    Rimmele, Thomas
    Monneret, Guillaume
    [J]. ANNALS OF INTENSIVE CARE, 2022, 12 (01)
  • [69] Granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients presenting sepsis-induced immunosuppression: The GRID randomized controlled trial
    Vacheron, Charles-Herve
    Lepape, Alain
    Venet, Fabienne
    Monneret, Guillaume
    Gueyffier, Francois
    Boutitie, Florent
    Vallin, Helene
    Schwebel, Carole
    Maucort-Boulch, Delphine
    Friggeri, Arnaud
    [J]. JOURNAL OF CRITICAL CARE, 2023, 78
  • [70] Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes
    van Amstel, Rombout B. E.
    Kennedy, Jason N.
    Scicluna, Brendon P.
    Bos, Lieuwe D. J.
    Peters-Sengers, Hessel
    Butler, Joe M.
    Cano-Gamez, Eddie
    Knight, Julian C.
    Vlaar, Alexander P. J.
    Cremer, Olaf L.
    Angus, Derek C.
    van der Poll, Tom
    Seymour, Christopher W.
    van Vught, Lonneke A.
    [J]. INTENSIVE CARE MEDICINE, 2023, 49 (11) : 1360 - 1369