Cognitive resilience in Alzheimer's disease: Mechanism and potential clinical intervention

被引：0
|
作者：
Jia, Bin [1 ,2 ]
Xu, Yun [1 ,3 ,4 ,5 ,6 ]
Zhu, Xiaolei [1 ,3 ,4 ,5 ,6 ]
机构：
[1] Jiangsu Univ, Nanjing Drum Tower Hosp, Sch Med, Dept Neurol, Nanjing, Jiangsu, Peoples R China
[2] Jiangsu Univ, Affiliated Hosp 4, Dept Neurol, Zhenjiang, Jiangsu, Peoples R China
[3] Nanjing Univ, Jiangsu Key Lab Mol Med, Nanjing, Peoples R China
[4] Nanjing Univ, Inst Translat Med Brain Crit Dis, Nanjing, Peoples R China
[5] Nanjing Neurol Clin Med Ctr, Nanjing, Peoples R China
[6] Nanjing Drum Tower Hosp, Brain Dis & Brain Sci Ctr, Nanjing, Peoples R China
来源：
AGEING RESEARCH REVIEWS | 2025年 / 106卷
关键词：
Alzheimer's disease; Pathology; Resilience; Diagnosis; Personalized intervention strategies; TRANSCRANIAL MAGNETIC STIMULATION; AMYLOID PRECURSOR PROTEIN; DENDRITIC SPINES; PHYSICAL-ACTIVITY; OLDER-ADULTS; BETA; DEMENTIA; EXERCISE; MEMORY; NEUROPATHOLOGY;
D O I：
10.1016/j.arr.2025.102711
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Alzheimer's disease (AD) is a globally recognized neurodegenerative disorder that severely impairs cognitive function and imposes substantial psychological and financial burdens on patients and their families. The hallmark pathological features of AD include progressive neurodegeneration, extracellular beta-amyloid (A(3) plaque accumulation, and intracellular hyperphosphorylated tau protein tangles. However, recent studies have identified a subset of patients exhibiting cognitive resilience, characterized by a slower cognitive decline or the preservation of high cognitive function despite the presence of AD pathology. Cognitive resilience is influenced by a complex interplay of genetic, environmental, and lifestyle factors. In addition, cognitive resilience contributes to the new perspectives on the diagnosis and personalized treatment of AD. This review aims to provide a comprehensive analysis of current studies on cognitive resilience in AD and to explore future research directions of AD diagnosis and treatment.
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页数：8
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