Deciphering the Potentials of Cardamom in Cancer Prevention and Therapy: From Kitchen to Clinic

被引:4
作者
Bano, Shabana [1 ]
Majumder, Avisek [1 ]
Srivastava, Ayush [2 ]
Nayak, Kasturi Bala [3 ]
机构
[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94158 USA
[2] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94158 USA
[3] Univ Calif San Francisco, Quantitat Biosci Inst, Dept Med, San Francisco, CA 94158 USA
关键词
cancer prevention; chemoprotectant; chemoprevention; Elettaria cardamomum; ayurveda; inflammation; antioxidants; anti-microbial; diet; cancer therapy; epigenetics; natural medicine; pharmacological use; traditional Indian medicine; phytochemicals; flavonoids; CELL-CYCLE ARREST; KAPPA-B PATHWAY; IN-VITRO; BREAST-CANCER; ESSENTIAL OILS; HYDROGEN-SULFIDE; LUNG-CANCER; ANTIOXIDANT; PROLIFERATION; APOPTOSIS;
D O I
10.3390/biom14091166
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cardamom (cardamum) is a spice produced from the seeds of several Elettaria and Amomum plants of the Zingiberaceae family. Cardamom has been demonstrated to offer numerous benefits, including its antioxidant, antimicrobial, anti-inflammatory, and other metabolic (anti-diabetic) properties, and its potential to reduce cancer risk. Recently, researchers have extracted and tested multiple phytochemicals from cardamom to assess their potential effectiveness against various types of human malignancy. These studies have indicated that cardamom can help overcome drug resistance to standard chemotherapy and protect against chemotherapy-induced toxicity due to its scavenging properties. Furthermore, chemical compounds in cardamom, including limonene, cymene, pinene, linalool, borneol, cardamonin, indole-3-carbinol, and diindolylmethane, primarily target the programmed cell death lignin-1 gene, which is more prevalent in cancer cells than in healthy cells. This review provides the medicinal properties and pharmacological uses of cardamom, its cellular effects, and potential therapeutic uses in cancer prevention and treatment, as well as its use in reducing drug resistance and improving the overall health of cancer patients. Based on previous preclinical studies, cardamom shows significant potential as an anti-cancer agent, but further exploration for clinical use is warranted due to its diverse mechanisms of action.
引用
收藏
页数:21
相关论文
共 189 条
[1]  
Abdullah Asghar A., 2017, J FOOD SCI TECH MYS, V54, P2306, DOI [10.1007/s13197-017-2668-7, DOI 10.1007/s13197-017-2668-7]
[2]   Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial [J].
Aghasi, Mohadeseh ;
Koohdani, Fariba ;
Qorbani, Mostafa ;
Nasli-Esfahani, Ensieh ;
Ghazi-Zahedi, Shohreh ;
Khoshamal, Hoorieh ;
Keshavarz, Ali ;
Sotoudeh, Gity .
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2019, 99 (08) :3933-3940
[3]   Recent advances in the extraction, chemical composition, therapeutic potential, and delivery of cardamom phytochemicals [J].
Ahmad, Naveed ;
Tian, Wenni ;
Zengliu, Song ;
Zou, Yucheng ;
Farooq, Shahzad ;
Huang, Qingrong ;
Xiao, Jie .
FRONTIERS IN NUTRITION, 2022, 9
[4]  
Ahmed AS, 2017, PAK J PHARM SCI, V30, P113
[5]  
Akrayi H.F.S., 2012, Tikrit J. Pure Sci, V17, P14
[6]   Solar energy-based extraction of essential oils from cloves, cinnamon, orange, lemon, eucalyptus, and cardamom: A clean energy technology for green extraction [J].
Al-Hilphy, Asaad Rehman ;
Ahmed, Abdul-Hadi K. ;
Gavahian, Mohsen ;
Chen, Ho-Hsien ;
Chemat, Farid ;
Al-Behadli, Thamer K. M. ;
Nor, Mohd Zuhair Mohd ;
Ahmad, So'bah .
JOURNAL OF FOOD PROCESS ENGINEERING, 2022, 45 (06)
[7]  
Alemdar S., 2005, YY Vet Fak Derg, V16, P99
[8]  
Ali M.L., 2024, Cancer Pathog. Ther, V2, pE082, DOI [10.1016/j.cpt.2024.07.003, DOI 10.1016/J.CPT.2024.07.003]
[9]   Pharmacological studies of cardamom oil in animals [J].
AlZuhair, H ;
ElSayeh, B ;
Ameen, HA ;
AlShoora, H .
PHARMACOLOGICAL RESEARCH, 1996, 34 (1-2) :79-82
[10]   Total Antioxidant Capacity and Change in Phytochemicals of Four Major Varieties of Cardamom Oils During Decortication [J].
Amma, K. P. Padmakumari ;
Sasidharan, Indu ;
Sreekumar, M. M. ;
Sumathykutty, M. A. ;
Arumughan, C. .
INTERNATIONAL JOURNAL OF FOOD PROPERTIES, 2015, 18 (06) :1317-1325