ISPAD Clinical Practice Consensus Guidelines 2024: Screening, Staging, and Strategies to Preserve Beta-Cell Function in Children and Adolescents with Type 1 Diabetes

被引：2

作者：

Haller, Michael J. ^{[1
]}

Bell, Kirstine J. ^{[2
,3
]}

Besser, Rachel E. J. ^{[4
]}

Casteels, Kristina ^{[5
,6
]}

Couper, Jenny J. ^{[7
,8
]}

Craig, Maria E. ^{[9
,10
,11
]}

Larsson, Helena Elding ^{[12
,13
]}

Jacobsen, Laura ^{[1
]}

Lange, Karin ^{[14
]}

Oron, Tal ^{[15
]}

Sims, Emily K. ^{[16
]}

Speake, Cate ^{[17
]}

Tosur, Mustafa ^{[18
,19
]}

Ulivi, Francesca ^{[20
]}

Ziegler, Anette-G. ^{[21
,22
]}

Wherrett, Diane K. ^{[23
]}

Marcovecchio, M. Loredana ^{[24
,25
]}

机构：

[1] Univ Florida, Dept Pediat, Div Endocrinol, Gainesville, FL 32611 USA

[2] Charles Perkins Ctr, Sydney, NSW, Australia

[3] Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia

[4] Univ Oxford, Ctr Human Genet, NIHR Biomed Res Ctr, Oxford, England

[5] Univ Hosp Leuven, Dept Pediat, Leuven, Belgium

[6] Katholieke Univ Leuven, Dept Dev & Regenerat, Leuven, Belgium

[7] Womens & Childrens Hosp, North Adelaide, SA, Australia

[8] Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia

[9] Childrens Hosp Westmead, Sydney, NSW, Australia

[10] Univ Sydney, Discipline Pediat & Child Hlth, Sydney, NSW, Australia

[11] Univ New South Wales, Sch Womens & Childrens Hlth, Sydney, NSW, Australia

[12] Lund Univ, Dept Clin Sci Malmo, Lund, Sweden

[13] Skane Univ Hosp, Dept Pediat, Lund, Sweden

[14] Hannover Med Sch, Dept Med Sociol, Hannover, Germany

[15] Schneider Childrens Med Ctr Israel, Inst Endocrinol & Diabet, Petah Tiqwa, Israel

[16] Indiana Univ, Sch Med, Indianapolis, IN USA

[17] Benaroya Res Inst Virginia Mason, Ctr Intervent Immunol, Seattle, WA USA

[18] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Div Diabet & Endocrinol, Houston, TX USA

[19] USDA ARS, Childrens Nutr Res Ctr, Houston, TX USA

[20] CNR, Milan, Italy

[21] Tech Univ Munich, Helmholtz Zentrum Munchen, Klinikum Rechts Isar, D-80804 Munich, Germany

[22] Tech Univ Munich, Klinikum rechts Isar, Forschergruppe Diabet, Munich, Germany

[23] Univ Toronto, Hosp Sick Children, Dept Pediat, Div Endocrinol & Metab, Toronto, ON, Canada

[24] Cambridge Univ Hosp NHS Fdn Trust Cambridge, Dept Paediat Orthopaed, Cambridge, England

[25] Cambridge Univ Hosp NHS Fdn Trust, Cambridge, England

来源：

HORMONE RESEARCH IN PAEDIATRICS | 2025年 / 97卷 / 06期

关键词：

Screening; Stages; Preservation; Beta cell; Children; Type; 1; diabetes; MULTIPLE ISLET AUTOANTIBODIES; DISEASE-MODIFYING THERAPY; GENETIC RISK; GENERAL-POPULATION; PLASMA-GLUCOSE; C-PEPTIDE; HLA-DR; PROGRESSION; ONSET; KETOACIDOSIS;

D O I：

10.1159/000543035

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines represent a rich repository that serves as the only comprehensive set of clinical recommendations for children, adolescents, and young adults living with diabetes worldwide. This guideline serves as an update to the 2022 ISPAD consensus guideline on staging for type 1 diabetes (T1D). Key additions include an evidence-based summary of recommendations for screening for risk of T1D and monitoring those with early-stage T1D. In addition, a review of clinical trials designed to delay progression to Stage 3 T1D and efforts seeking to preserve beta-cell function in those with Stage 3 T1D are included. Lastly, opportunities and challenges associated with the recent US Food and Drug Administration (FDA) approval of teplizumab as an immunotherapy to delay progression are discussed.

引用

页码：529 / 545

页数：17

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