A Review of the Pathogenesis of IgA Vasculitis Nephritis in Children

被引:1
作者
Li, Qianqian [1 ]
Chen, Rong [2 ]
An, Hongj in [3 ]
Tang, Yuying [1 ]
Yang, Baowang [1 ]
机构
[1] Lanzhou Univ, Dept Pediat, Hosp 2, Lanzhou, Gansu, Peoples R China
[2] Pingliang Second Peoples Hosp, Dept Pediat, Pingliang, Gansu, Peoples R China
[3] Lanzhou Univ, Gen Med Dept, Hosp 2, Lanzhou, Gansu, Peoples R China
关键词
Children; Henoch-Schonlein Purpura Nephritis; IgA Vasculitis Nephritis; Pathogenesis; Anaphylactoid Purpura; HENOCH-SCHONLEIN PURPURA; CHINESE HERBAL MEDICINE; THROMBOCYTOPENIC PURPURA; GLOMERULONEPHRITIS; NEPHROPATHY; ASSOCIATION; DEFICIENCY; RECURRENCE; EXPRESSION; THROMBOSIS;
D O I
10.5812/ijp-150310
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
In children, IgA Vasculitis (IgAV), formerly known as Henoch-Sch & ouml;nlein purpura, is a common kidney illness primarily caused by anaphylactoid purpura. It is highly prevalent among youngsters, often presenting with symptoms such as skin purpura, abdominal pain, and hematuria. In some cases, IgA vasculitis nephritis (IgAVN) may progress to chronic kidney disease (CKD),exacerbating renal function impairment and negatively impacting patient prognosis. To effectively develop preventive and therapeutic strategies for pediatric IgAVN, a comprehensive understanding of its pathogenesis is crucial. This review discusses the involvement of key biological markers, including galactose-deficient IgA1, C-reactive protein, and inflammatory cytokines,in the disease's pathophysiology. Additionally, it provides an overview of the specific diagnostic markers and clinical management strategies pertinent to this condition.
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页数:10
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