Zebrafish as a Model System for Brugada Syndrome

被引:1
作者
Verkerk, Leonie [1 ]
Verkerk, Arie O. [1 ,2 ]
Wilders, Ronald [1 ]
机构
[1] Univ Amsterdam, Dept Med Biol, Amsterdam Cardiovasc Sci, Amsterdam UMC, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Heart Ctr, Dept Expt Cardiol, Amsterdam Cardiovasc Sci,Amsterdam UMC, NL-1105 AZ Amsterdam, Netherlands
关键词
Brugada syndrome; zebrafish; Danio rerio; human; heart; ventricle; cardiomyocytes; electrophysiology; action potential; sodium current; ST-SEGMENT ELEVATION; BUNDLE-BRANCH BLOCK; SUDDEN CARDIAC DEATH; LONG-TERM PROGNOSIS; VENTRICULAR-FIBRILLATION; RISK STRATIFICATION; ELECTRICAL STORM; QT SYNDROME; QUINIDINE; DISEASE;
D O I
10.31083/j.rcm2509313
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Brugada syndrome (BrS) is an inheritable cardiac arrhythmogenic disease, associated with an increased risk of sudden cardiac death. It is most common in males around the age of 40 and the prevalence is higher in Asia than in Europe and the United States. The pathophysiology underlying BrS is not completely understood, but several hypotheses have been proposed. So far, the best effective treatment is the implantation of an implantable cardioverter-defibrillator (ICD), but device-related complications are not uncommon. Therefore, there is an urgent need to improve diagnosis and risk stratification and to find new treatment options. To this end, research should further elucidate the genetic basis and pathophysiological mechanisms of BrS. Several experimental models are being used to gain insight into these aspects. The zebrafish (Danio rerio) is a widely used animal model for the study of cardiac arrhythmias, as its cardiac electrophysiology shows interesting similarities to humans. However, zebrafish have only been used in a limited number of studies on BrS, and the potential role of zebrafish in studying the mechanisms of BrS has not been reviewed. Therefore, the present review aims to evaluate zebrafish as an animal model for BrS. We conclude that zebrafish can be considered as a valuable experimental model for BrS research, not only for gene editing technologies, but also for screening potential BrS drugs.
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页数:16
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