Risk of rhabdomyolysis in patients with mental disorders

被引:0
作者
Lu, Ya-Wen [1 ]
Wang, Jong-Yi [2 ]
Hsu, Tzu-Ju [3 ]
Chung, Wei-Sheng [2 ,4 ,5 ]
机构
[1] Taichung Hosp, Minist Hlth & Welf, Pharmaceut Dept, Taichung, Taiwan
[2] China Med Univ, Dept Hlth Serv Adm, Taichung, Taiwan
[3] China Med Univ Hosp, Clin Trial Res Ctr CTC, Management Off Hlth Data DryLab, Taichung, Taiwan
[4] Taichung Hosp, Minist Hlth & Welf, Dept Internal Med, 199 Sect 1,San Min Rd, Taichung 40343, Taiwan
[5] Cent Taiwan Univ Sci & Technol, Dept Healthcare Adm, Taichung, Taiwan
关键词
Rhabdomyolysis; mental disorders; alcoholic liver disease; generalized convulsive epilepsy; phenothiazines; butyrophenone; SCHIZOPHRENIA; DOPAMINE; DRUGS;
D O I
10.1080/00325481.2025.2466411
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
ObjectivesRhabdomyolysis is caused by rapid muscle breakdown. Although patients with mental disorders are more susceptible to rhabdomyolysis, its incidence in this group is poorly established. Therefore, we conducted a population-based cohort study to investigate its incidence and risk in this group.MethodsWe conducted a retrospective cohort study of 120,094 patients with mental disorders and 120,094 control patients from the Taiwan National Health Insurance Research Database. We excluded patients with rhabdomyolysis diagnosed before the index date, which was defined as the date of the first diagnosis of the mental disorder and beginning of antipsychotic medication. We matched the case cohort 1:1 with a control cohort by a propensity score method.ResultsThe overall incidence of rhabdomyolysis were 3.21 per 1000 person-years in the patients with mental disorders and 1.16 per 1000 person-years in the patients without mental disorders. After controlling for potential covariates, the patients with mental disorders showed an adjusted hazard ratio (aHR) of 2.77 (95% Cl: 2.62-2.92) compared with the controls. Men exhibited a risk of rhabdomyolysis 1.29-fold that exhibited by women (95% CI: 1.22-1.35). Alcoholic liver disease (aHR, 2.35) and generalized convulsive epilepsy (aHR, 2.06) were independent risk factors for rhabdomyolysis. Phenothiazines with aliphatic side-chains (aHR, 1.43), or piperidine structures (aHR, 1.54); butyrophenone derivatives (aHR, 1.24); lithium (aHR, 1.18) were independent risk factors for rhabdomyolysis after adjustment for covariates.ConclusionsThe risk of rhabdomyolysis is significantly higher for patients with mental disorders than that for patients without mental disorders.
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收藏
页码:201 / 208
页数:8
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