Acute respiratory tract infections during the first 6 years of life - results from the German birth cohort study LoewenKIDS

被引：0

作者：

Klee, Bianca ^{[1
]}

Diexer, Sophie ^{[1
]}

Langer, Susan ^{[1
]}

Gottschick, Cornelia ^{[1
]}

Hartmann, Carla ^{[1
]}

Glaser, Nadine ^{[1
]}

Horn, Johannes ^{[1
]}

Dorendorf, Evelyn ^{[2
]}

Raupach-Rosin, Heike ^{[2
]}

Hassan, Lamiaa ^{[1
]}

Ruebsamen, Nicole ^{[3
]}

Meyer-Schlinkmann, Kristin Maria ^{[4
]}

Guzman, Carlos A. ^{[5
]}

Heselich, Valerie ^{[6
]}

Battin, Eva ^{[6
]}

Pietschmann, Thomas ^{[7
]}

Pieper, Dietmar H. ^{[8
]}

Pletz, Mathias ^{[9
]}

Riese, Peggy ^{[5
]}

Trittel, Stephanie ^{[5
]}

Thies, Saskia ^{[1
]}

von Kaisenberg, Constantin ^{[10
]}

Dressler, Frank ^{[11
]}

Guthmann, Florian ^{[12
]}

Oberhoff, Carsten ^{[13
]}

Schild, Ralf L. ^{[14
]}

Karch, Andre ^{[3
]}

Mikolajczyk, Rafael ^{[1
,2
]}

机构：

[1] Martin Luther Univ Halle Wittenberg, Inst Med Epidemiol Biometr & Informat, Interdisciplinary Ctr Hlth Sci, Med Fac, Halle, Saale, Germany

[2] Helmholtz Ctr Infect Res, Epidemiol Res Grp Epidemiol & Stat Methods, Braunschweig, Germany

[3] Univ Munster, Inst Epidemiol & Social Med, Munster, Germany

[4] MVZ Lab Krone eGbR, Siemensstr 40, Bad Salzuflen, Germany

[5] Helmholtz Ctr Infect Res, Dept Vaccinol & Appl Microbiol, Braunschweig, Germany

[6] LMU Ludwig Maximilians Univ Munich, Dr von Hauner Childrens Hosp, Dept Paediat, Munich, Germany

[7] TWINCORE, Inst Expt Virol, Ctr Expt & Clin Infect Res, Hannover, Germany

[8] Helmholtz Ctr Infect Res, Microbial Interact & Proc Res Grp, Braunschweig, Germany

[9] Jena Univ Hosp, Inst Infect Dis & Infect Control, Jena, Germany

[10] Hanover Med Sch, Dept Obstet Gynecol & Reprod Med, Hanover, NH USA

[11] Hannover Med Sch, Dept Pediat Pulmonol Allergol & Neonatol, Hannover, Germany

[12] Children & Youth Hosp Bult, Dept Neantol, Hannover, Germany

[13] Klinikum Links Weser, Dept Gynecol & Obstet, Bremen, Germany

[14] DIAKOVERE Henriettenstift Hanover, Dept Obstet & Perinatal Med, Hannover, Germany

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2025年 / 153卷

关键词：

Acute respiratory infections; Birth cohort study; Pediatric infections; Infection susceptibility; PRIMARY-CARE; CHILDREN; IMPACT; CHILDHOOD; ENGLAND; ILLNESS; DISEASE; BURDEN; ATOPY;

D O I：

10.1016/j.ijid.2025.107802

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives: Acute respiratory tract infections (ARIs) often occur in early childhood and are mostly self- limited. However, they impose a high socioeconomic burden and can be associated with chronic diseases later in life. To date, data on self-reported ARIs beyond infancy are limited. This study aimed to describe the incidence and characteristics of self-reported ARIs in the first 6 years of life. Methods: Data were obtained from the LoewenKIDS birth cohort study, including 782 children born between 2014 and 2018. Parents recorded daily ARI symptoms, which were classified into episodes for incidence and characteristics analysis. Regression analyses explored the influence of exposure factors on ARI incidence. Results: This longitudinal birth cohort study of a subsample of 258 children found a mean cumulative duration of 51.5 weeks (95% confidence interval: 47.5-55.6 weeks) of respiratory symptoms in the first 6 years of life, with large individual differences. Children with frequent infections in infancy had more infections in preschool age. Exposure factors explained only a small fraction of variation in incidence (5%). Conclusions: There is a substantial variation in susceptibility to ARIs in childhood, which is not explained by exposure factors. (c) 2025 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

引用

页数：7

共 31 条

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